Results 101 to 110 of about 1,079,572 (317)

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Information entropy and interaction optimization model based on swarm intelligence

, 2006
By introducing the information entropy H(X) and mutual information I(X; Y) of information theory into swarm intelligence, the Interaction Optimization Model (IOM) is proposed.
Niu B(牛奔), Zhu YL(朱云龙), Hu KY(胡琨元), He XX(何小贤)   +3 more
core  

Evolutionary optimization of echo state networks: multiple motor pattern learning

, 2010
Krause AF, Dürr V, Bläsing B, Schack T. Evolutionary optimization of echo state networks: multiple motor pattern learning. In: Artificial neural networks and intelligent information processing : proceedings of the 6th International Workshop on ...
Krause, André Frank, Bläsing, Bettina, Schack, Thomas, Dürr, Volker ; https://orcid.org/   +3 more
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Pest and Disease Prediction and Management for Sugarcane Using a Hybrid Autoregressive Integrated Moving Average—A Long Short-Term Memory Model

Agriculture
This study introduces a hybrid AutoRegressive Integrated Moving Average (ARIMA)—Long Short-Term Memory (LSTM) model for predicting and managing sugarcane pests and diseases, leveraging big data for enhanced accuracy.
Minghui Wang, Tong Li
doaj   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Robust Optimization of Currency Portfolios [PDF]

We study a currency investment strategy, where we maximize the return on a portfolio of foreign currencies relative to any appreciation of the corresponding foreign exchange rates. Given the uncertainty in the estimation of the future currency values, we
Berc Rustem, Raquel J. Fonseca, Steve Zymler, Wolfram Wiesemann   +3 more
core  

Model Calibration using ANN-ACCO Optimization Method [PDF]

, 2007
In order to properly simulate the natural phenomena using numerical model, model parameters have to be estimated by an appropriate manner. Here, new approach using ACCO and artificial neural network is proposed for the calibration of numerical simulation
野口, 正人, Solomatine, Dimitri P., 西田, 渉   +2 more
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Investigation of evolution strategy and optimization of induction heating model

, 2006
An optimal design method using the finite element method and the evolution strategy (ES) is investigated. The evolution strategy is applied to the optimization of induction heating model.
Horii, Makoto, Takahashi, Norio, Narita, Takashi   +2 more
core   +1 more source