Results 161 to 170 of about 1,079,572 (317)

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Maximizing gerrymandering through ising model optimization. [PDF]

Sci Rep, 2021
Okamoto Y.
europepmc   +1 more source

A general approach to Bayesian portfolio optimization [PDF]

We develop a general approach to portfolio optimization taking account of estimation risk and stylized facts of empirical finance. This is done within a Bayesian framework.
Bade, Alexander, Jaekel, Uwe, Frahm, Gabriel   +2 more
core  

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Retracted: Internet of Things and Edge Computing Model Optimization in Physical Training Status and Countermeasures in College Sports Basketball Optional Course. [PDF]

Comput Intell Neurosci, 2023
Intelligence And Neuroscience C.
europepmc   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Three-Dimensional Engine-Based Geometric Model Optimization Algorithm for BIM Visualization with Augmented Reality. [PDF]

Sensors (Basel), 2022
Aung PPW, Choi W, Kulinan AS, Cha G, Park S.   +4 more
europepmc   +1 more source

OSA90/hope™ User’s Manual Version 4.0 -- UNIX

, 1997
OSA90/hope is a general CAD software system offering simulation, modeling, statistical analysis, nominal and yield optimization, and data visualization for linear and nonlinear analog circuits. Its open architecture allows you to create fully optimizable
Bandler, John W., Biernacki, R.M., Chen, S.H., Optimization Systems Associates   +3 more
core  

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Main Features of Business English Translation and Teaching Model Optimization Based on the Logistic Model. [PDF]

Comput Intell Neurosci, 2022
Huang J.
europepmc   +1 more source