Results 161 to 170 of about 729,060 (268)

A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline

FEBS Open Bio, EarlyView.
Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey, Vaishnavi Sanjayan, Praveen Singh, Shantanu Sengupta, Anand Kumar Bachhawat   +4 more
wiley   +1 more source

Developing an AI-powered wound assessment tool: a methodological approach to data collection and model optimization. [PDF]

BMC Med Inform Decis Mak
Stefanelli A, Zahia S, Chanel G, Niri R, Pichon S, Probst S.   +5 more
europepmc   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Machine learning model optimization for flood susceptibility zonation over the Kosi megafan, Himalayan foreland basin, India. [PDF]

Sci Rep
Arora A, Durga G P, Pandey M, Arabameri A.   +3 more
europepmc   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Portable Electrical Impedance Prescreening for Breast tissue suspicious for malignancy: Model Optimization and Clinical Performance of the Julieta Device in a Multicenter Cross-Sectional Study in Colombia. [PDF]

Technol Cancer Res Treat
Negret MA, González V, Grajales D, Velez MA, Yepez MA, Agudelo V, Lopez S, Piedrahita C.   +7 more
europepmc   +1 more source

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source

Development of an AI model for pneumothorax imaging: Dataset and model optimization strategies for real-world deployment. [PDF]

Eur J Radiol Open
Tseng WC, Wang YC, Chen WC, Lin KP.
europepmc   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

Non-destructive detection of <i>Phyllostachys edulis</i> under salt stress using UHF RFID based on Cole-Cole model optimization algorithm. [PDF]

Front Plant Sci
Zhang W, Hou Z, Liu Y, Wu Y.
europepmc   +1 more source