Results 141 to 150 of about 729,060 (268)

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Machine learning model optimization with optuna for accurate prediction of strength and crack behavior in prestressed concrete beams. [PDF]

Sci Rep
Wen Y, Guo R, Duan Z, Tong Y, Tang X, Pan T, Fu C.   +6 more
europepmc   +1 more source

Diagnostic model optimization method for ADHD based on brain network analysis of resting-state fMRI images and transfer learning neural network. [PDF]

Front Hum Neurosci, 2022
Meng X, Zhuo W, Ge P, Zou B, Zhu Y, Liu W, Li X.   +6 more
europepmc   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

HOES: an efficient multi-evolutionary expert system for deep learning model optimization in time series prediction. [PDF]

Sci Rep
Wei P, Fan C, Yang X, Chen X, Gan J, Deng X, Wei Y, Li Z.   +7 more
europepmc   +1 more source

Study on Multi-Model Soft Sensor Modeling Method and Its Model Optimization for the Fermentation Process of Pichia pastoris. [PDF]

Sensors (Basel), 2021
Wang B, Wang X, He M, Zhu X.
europepmc   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Early Dengue Prediction in Bangladesh: A Comparative Study With Feature Analysis, Explainable Artificial Intelligence, and Model Optimization. [PDF]

J Trop Med
Bhuiyan MA, Akash MRS, Islam R, Polash SI, Khushbu SA.   +4 more
europepmc   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Serum uric acid-to-HDL-C ratio as an independent predictor of metabolic syndrome in the elderly: diagnostic model optimization and inflammatory mechanism insights. [PDF]

BMC Geriatr
Sun R, Hu M, Sun Z, Wang N, Wang J, Wu H, Yang J, Jin Y.   +7 more
europepmc   +1 more source