Results 41 to 50 of about 1,079,572 (317)

The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli, Seth Rotz, Masatoshi Takagi, Richa Sharma   +3 more
wiley   +1 more source

Self-adaptive root growth model for constrained multi-objective optimization

, 2013
This paper presents a general optimization model gleaned ideas from plant root growth behaviors in the soil. The purpose of the study is to investigate a novel biologically inspired methodology for complex system modelling and computation, particularly ...
Zhu YL(朱云龙), Hao Zhang, Zhang H(张浩), Yunlong Zhu, Dingyi Zhang, Zhang DY(张丁一)   +5 more
core   +1 more source

Therapeutic Apheresis in Nigeria: A Multi‐Center Summary of Abstracts From the Inaugural Nigerian Society for Apheresis Scientific Meeting

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Therapeutic apheresis (TA) is an established treatment modality for hematologic, neurologic, and immunologic disorders, yet access remains severely limited in sub‐Saharan Africa. Donor apheresis, including platelet apheresis collection from healthy donors, represents an important complementary modality supporting blood product ...
Nosa Bazuaye, Chimezie Okwuonu, Evelyn Idam, Folasade Adelekan‐Popoola, Shakirat Gold‐Olufadi, Olufunto Olufela Kalejaiye, Abdullateef Ogala, Zinnah Aloziem, Blossom Amamchukwu, Patience Elimia, Mkpoikanabasi Obot‐Obot, Henry Mbakwe, Praises Maduagwuna, Olatunji Akinrodoye, Chiamaka Anyanwu, Benjamin Anyanwu, Adedamola Akinsiku, Oluwatoyin A. Akinsiku, Muzamil O. Hassan, Fatiu A. Arogundade, Olalekan E. Ojo, Homayemem Weli, Jesupelumi Adenihun, Aderemi Adelaja, Ebun Bamgboye, Olalekan Olatise, Ade E. Faponle, Ayoola Odeyemi, Michael Muoka, Stephen Asaolu, Qudrat Busari, Blessing Dawudu, Michael Naiyeju, Rasheed A. Balogun   +33 more
wiley   +1 more source

Gaussian process-based quasi-coherent noise suppression in magnetic confinement devices with superconductors

Nuclear Fusion, 2023
Gaussian process (GP)-based technique suppressing quasi-coherent noises, i.e. structured noises, is developed which is more effective than conventional denoising techniques such as using frequency-domain filters. Superconducting devices like KSTAR, EAST,
Jaewook Kim, Jayhyun Kim, Y.-c. Ghim, Juhyeok Jang   +3 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Global Optimization Based on Hierarchical Coevolution Model

, 2008
This paper presents a novel optimization algorithm that we call the particle swarms swarm optimizer ((PSO)-O-2), which based on a hierarchical coevolution model (HCO model) of symbiotic species. HCO model introduced a number of M species each possesses a
Y. L. Zhu, H. N. Chen, T. Ku, Chen HN(陈瀚宁), Zhu YL(朱云龙), K. Y. Hu, Ku T(库涛), Hu KY(胡琨元)   +7 more
core   +1 more source

Addressing the impact of environmental uncertainty in plankton model calibration with a dedicated software system: the Marine Model Optimization Testbed (MarMOT 1.1 alpha) [PDF]

, 2012
A wide variety of different plankton system models have been coupled with ocean circulation models, with the aim of understanding and predicting aspects of environmental change.
Challenor, P.G., P. G. Challenor, Hemmings, J.C.P., J. C. P. Hemmings   +3 more
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

MRP-YOLO: An Improved YOLOv8 Algorithm for Steel Surface Defects

Machines
The existing detection algorithms are unable to achieve a suitable balance between detection accuracy and inference speed. As the accuracy of the algorithm increases, its complexity also rises, resulting in a decrease in detection speed, which undermines
Shuxian Zhu, Yajie Zhou
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source