Results 61 to 70 of about 1,079,572 (317)

An Optimal Model to Improve Genomic Prediction for Protein Content and Test Weight in a Diverse Spring Wheat Panel

Agriculture
In recent years, genomic selection has been widely used in plant breeding to increase genetic gain. Selections are based on breeding values of each genotype estimated using genome-wide markers.
Pabitra Joshi, Guriqbal Singh Dhillon, Yaotian Gao, Amandeep Kaur, Justin Wheeler, Jianli Chen   +5 more
doaj   +1 more source

Optimization of Traced Neuron Skeleton Using Lasso-Based Model

Frontiers in Neuroanatomy, 2019
Reconstruction of neuronal morphology from images involves mainly the extraction of neuronal skeleton points. It is an indispensable step in the quantitative analysis of neurons.
Shiwei Li, Shiwei Li, Tingwei Quan, Tingwei Quan, Tingwei Quan, Cheng Xu, Cheng Xu, Qing Huang, Qing Huang, Hongtao Kang, Hongtao Kang, Yijun Chen, Yijun Chen, Anan Li, Anan Li, Ling Fu, Ling Fu, Qingming Luo, Qingming Luo, Hui Gong, Hui Gong, Shaoqun Zeng, Shaoqun Zeng   +22 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Augmentation for Accuracy Improvement of YOLOv8 in Blind Navigation System

Jurnal RESTI (Rekayasa Sistem dan Teknologi Informasi)
This study addresses the critical need for enhanced accuracy in YOLOv8 models designed for visually impaired navigation systems. Existing models often struggle with consistency in object detection and distance estimation under varying environmental ...
Erwin Syahrudin, Ema Utami, Anggit Dwi Hartanto   +2 more
doaj   +1 more source

Global Optimization of Ventricular Myocyte Model to Multi-Variable Objective Improves Predictions of Drug-Induced Torsades de Pointes

Frontiers in Physiology, 2017
In silico cardiac myocyte models present powerful tools for drug safety testing and for predicting phenotypical consequences of ion channel mutations, but their accuracy is sometimes limited.
Trine Krogh-Madsen, Trine Krogh-Madsen, Trine Krogh-Madsen, Anna F. Jacobson, Francis A. Ortega, David J. Christini, David J. Christini, David J. Christini   +7 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Empirical Validation of a Thermal Model of a Complex Roof Including Phase Change Materials

Energies, 2015
This paper deals with the empirical validation of a building thermal model of a complex roof including a phase change material (PCM). A mathematical model dedicated to PCMs based on the heat apparent capacity method was implemented in a multi-zone ...
Stéphane Guichard, Frédéric Miranville, Dimitri Bigot, Bruno Malet-Damour, Teddy Libelle, Harry Boyer   +5 more
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source