Results 131 to 140 of about 8,027,948 (326)

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Model Order Reduction Methods for Rotating Electrical Machines: A Review

Energies
Due to the rise of e-mobility applications, there is an increased demand to create more accurate control methods, which can reduce the loss in an e-drive system.
Kristóf Levente Kiss, Tamás Orosz
doaj   +1 more source

On the stability of projection-based model order reduction for convection-dominated laminar and turbulent flows [PDF]

Journal of Computational Physics, 2020
Sebastian Grimberg, C. Farhat, Noah Youkilis   +2 more
semanticscholar   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

A Forecast Test for Reducing Dynamical Dimensionality of Model Emulators

Journal of Advances in Modeling Earth Systems
The climate system can be numerically represented by a set of physically based dynamical equations whose solution requires substantial computational resources.
Tongtong Xu, Matthew Newman, Michael A. Alexander, Antonietta Capotondi   +3 more
doaj   +1 more source

Model order reduction of thermo-mechanical models with parametric convective boundary conditions: focus on machine tools. [PDF]

Comput Mech, 2021
Hernández-Becerro P, Spescha D, Wegener K.   +2 more
europepmc   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Efficient Analysis of Structures with Rotatable Elements Using Model Order Reduction [PDF]

Radioengineering, 2016
This paper presents a novel full-wave technique which allows for a fast 3D finite element analysis of waveguide structures containing rotatable tuning elements of arbitrary shapes.
G. Fotyga, K. Nyka
doaj  

Model order reduction with applications [PDF]

, 2021
Model order reduction is an integral approach to solving high-dimensional systems of ordinary and partial differential equations. As the needs for processing large amounts of data, resulting in high-order models, are only increasing, this approach will understandably stay relevant. Reduced basis methods are discussed, with the focus being on the proper
openaire  

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source