Results 121 to 130 of about 24,860,274 (294)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Model order reduction preconditioning of parameterized Poisson equations

四川大学学报. 自然科学版
This paper aims at the fast numerical solution of parameterized Poisson equation.A preconditioned conjugate gradient （PCG） method based on the model order reduction method is proposed to speed up the solution of the obtained discrete linear system.First，
HU Qixiao, XU Youcai, ZHANG Shiquan
doaj  

Model Order Reduction Methods for Rotating Electrical Machines: A Review

Energies
Due to the rise of e-mobility applications, there is an increased demand to create more accurate control methods, which can reduce the loss in an e-drive system.
Kristóf Levente Kiss, Tamás Orosz
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

morgen - Model Order Reduction for Gas and Energy Networks

, 2020
morgen - Model Order Reduction for Gas and Energy Networks (Version: 1 ...
Grundel, Sara, Himpe, Christian
core   +1 more source

Model order reduction of flow based on a modular geometrical approximation of blood vessels. [PDF]

Comput Methods Appl Mech Eng, 2021
Pegolotti L, Pfaller MR, Marsden AL, Deparis S.   +3 more
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Model Order Reduction of Vehicle Air-Conditioning Loop with Neural Networks

Engineering Perspective
To meet the energy demand, passenger’s comfort and sustainability in the air conditioning system of vehicles, the Neural Network plays an intelligent role. In this study, the vehicle air conditioning loop was replaced with the reduced control model using
Dr. Shıvakumar Nagareddy, Ravi Subramanyam, Vijay Govindarasu, Veeramani Neelakandan   +3 more
doaj   +1 more source

Model order reduction of thermo-mechanical models with parametric convective boundary conditions: focus on machine tools. [PDF]

Comput Mech, 2021
Hernández-Becerro P, Spescha D, Wegener K.   +2 more
europepmc   +1 more source