Results 111 to 120 of about 24,860,274 (294)

The Application of Model Order Reduction Methods to a Linear Cross-Diffusion Model

Journal of Mathematical Sciences and Modelling
This work investigates reduced-order modelling (ROM) strategies for the Brusselator system, a linear cross-diffusion framework with applications in chemical and biological systems.
Gülden Mülayim
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Interconnection-based model order reduction - a survey

European Journal of Control
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Scarciotti, G, Astolfi, A
openaire   +5 more sources

Adaptive chemical model reduction

, 2005
We briefly review various chemical model reduction strategies with application in reacting flow computations. We focus on systematic methods that enable automated model reduction.
J. C. Lee, Goussis, D, M. Frenklach, Lee, J, Valorani, M, D. A. Goussis, Najm, H, H. N. Najm, Frenklach, M, VALORANI, Mauro   +9 more
core   +1 more source

Model order reduction for bifurcating phenomena in fluid-structure interaction problems. [PDF]

Int J Numer Methods Fluids, 2022
Khamlich M, Pichi F, Rozza G.
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Model Order Reduction for Structured Second Order DAE Systems

, 2014
We present implicit index-reduction based model reduction for constrained mechanical systems.Presented at Tegernsee Workshop ...
Saak, Jens, Voigt, Matthias, Uddin, M. Monir, Ahmad, Mian Iljas   +3 more
core   +1 more source

Data-driven kinematics-consistent model order reduction of fluid-structure interaction problems: application to deformable microcapsules in a Stokes flow. [PDF]

J Fluid Mech, 2023
Dupont C, De Vuyst F, Salsac AV.
europepmc   +1 more source