Results 91 to 100 of about 24,860,274 (294)

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Balanced Realization and Model Order Reduction for Nonlinear Systems Based on Singular Value Analysis [PDF]

, 2004
This paper discusses balanced realization and model order reduction for both continuous-time and discrete-time general nonlinear systems based on singular value analysis of the corresponding Hankel operators.
Fujimoto, Kenji, Scherpen, Jacquelien M.A.,, Jacquelien M. A. Scherpen, Scherpen, Jacquelien M.A., Fujimoto, Kenji,, Scherpen, Jacquelien M. A., Kenji Fujimoto   +6 more
core   +2 more sources

Structured Model Order Reduction of System-Level Power Delivery Networks

IEEE Access
This paper proposes a comprehensive model order reduction framework to enable fast power integrity verification at the system level. This approach is developed to compress models of complete power delivery networks of high-end multiprocessor systems ...
Antonio Carlucci, Stefano Grivet-Talocia, Siddharth Kulasekaran, Kaladhar Radhakrishnan   +3 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Balanced truncation model reduction of periodic systems [PDF]

, 2000
The balanced truncation approach to model reduction is considered for linear discrete-time periodic systems with time-varying dimensions. Stability of the reduced model is proved and a guaranteed additive bound is derived for the approximation error ...
Varga, Andras
core  

Model Order Reduction for Simulation and Control of Synchronous Machines [PDF]

, 2019
Model order reduction approaches aim at reducing the computational complexity of numericalmodels. The reduction is achieved by lowering the dimension of the state space or the numberof degrees of freedom in the original high-order model, which in return ...
Farzam Far, Mehrnaz
core   +1 more source

Computational multiscale modeling of fracture problems and its model order reduction

, 2017
This work focuses on the numerical modeling of fracture and its propagationin heterogeneous materials by means of hierarchical multiscale models basedon the FE2 method, addressing at the same time, the problem of the excessivecomputational cost through ...
Oliver, X., Huespe, Alfredo Edmundo, Caicedo, M.A.   +2 more
core   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

New Numerical Software for Model and Controller Reduction [PDF]

, 2002
In this report we describe the recently developed model and controller reduction software for SLICOT within Task II.B of the NICONET Project. A powerful collection of user callable Fortran 77 routines has been implemented based on the latest algorithmic ...
Varga, Andras
core  

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source