Results 81 to 90 of about 4,816,952 (284)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Study of the model-order reduction of the aerolastic behavior of a wing [PDF]

, 2016
The  ultimate goal of this project is to construct a   reduced-order model capable of  providing real-time predictions of   the aeroelastic behavior of a wing.
Rodeja Ferrer, Pep
core  

Model Order Reduction for Seismic Applications

SIAM Journal on Scientific Computing
26 pages, plus supplementary ...
Rhys Hawkins, Muhammad Hamza Khalid, Matthias Schlottbom, Kathrin Smetana   +3 more
openaire   +3 more sources

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Geometric Model Order Reduction

, 2018
During the past decade, model order reduction (MOR) has been successfully applied to reduce the computational complexity of elliptic and parabolic systems of partial differential equations (PDEs). However, MOR of hyperbolic equations remains a challenge.
openaire   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Reduced Order Modeling and Sliding Mode Control of Active Magnetic Bearing

IEEE Access, 2019
Due to the accelerated growth in the field of power electronics and controller design techniques, the usage of the active magnetic bearing has picked up in industries. Active magnetic bearing helps the rotor to rotate freely without any physical contact.
Sudipta Saha, Syed Muhammad Amrr, Mashuq Un Nabi, Atif Iqbal   +3 more
doaj   +1 more source

POD model order reduction with space-adapted snapshots for incompressible flows

, 2019
We consider model order reduction based on proper orthogonal decomposition (POD) for unsteady incompressible Navier-Stokes problems, assuming that the snapshots are given by spatially adapted finite element solutions.
Gräßle, Carmen, Hinze, Michael, Lang, Jens, Ullmann, Sebastian   +3 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source