Results 81 to 90 of about 24,860,274 (294)

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Model Order Reduction in Fluid Dynamics: Challenges and Perspectives [PDF]

, 2014
This chapter reviews techniques of model reduction of fluid dynamics systems. Fluid systems are known to be difficult to reduce efficiently due to several reasons.
Lassila, Toni Mikael, Quarteroni, Alfio, Manzoni, A, Quarteroni, A, Rozza, Gianluigi, Rozza, G, Lassila, T, Manzoni, A., Andrea Manzoni, Gianluigi Rozza, Lassila, T., Quarteroni, A., Alfio Quarteroni, Toni Lassila, Rozza, G., Manzoni, Andrea   +15 more
core   +2 more sources

Model order reduction for a flow past a wall-mounted cylinder

Archives of Mechanics, 2016
Reduced order models allow quickly predict fluid behaviour and to better understand flow phenomena. They are the key enablers of closed-loop flow control.
W. Stankiewicz, K. Kotecki, M. Morzyński, R. Roszak, W. Szeliga   +4 more
doaj   +1 more source

A Review of Model Order Reduction Methods for Large-Scale Structure Systems

Shock and Vibration, 2021
The large-scale structure systems in engineering are complex, high dimensional, and variety of physical mechanism couplings; it will be difficult to analyze the dynamic behaviors of complex systems quickly and optimize system parameters.
Kuan Lu, Kangyu Zhang, Haopeng Zhang, Xiaohui Gu, Yulin Jin, Shibo Zhao, Chao Fu, Yongfeng Yang   +7 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

MORLAB - Model Order Reduction LABoratory

, 2017
<p>The MORLAB, Model Order Reduction LABoratory, toolbox is a collection of MATLAB routines for model order reduction of dynamical systems based on the solution of matrix equations.
Werner, Steffen W. R., Benner, Peter, Werner, S., Benner, P. ; https://orcid.org/   +3 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Nonlinear Parameter Space and Model Order Reductions enhanced by scientific machine learning

, 2023
Two of the main critical issues of model order reduction are the curse of dimensionality and the slow Kolmogorov n-width decay. With this thesis we want to provide novel methodologies that can ameliorate them: for the former we develop nonlinear ...
ROMOR, FRANCESCO
core