Results 101 to 110 of about 4,816,952 (284)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Model order reduction for bifurcating phenomena in fluid-structure interaction problems. [PDF]
Int J Numer Methods Fluids, 2022 Khamlich M, Pichi F, Rozza G.
europepmc +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Data-driven kinematics-consistent model order reduction of fluid-structure interaction problems: application to deformable microcapsules in a Stokes flow. [PDF]
J Fluid Mech, 2023 Dupont C, De Vuyst F, Salsac AV.
europepmc +1 more source
NKCC1: A key regulator of glioblastoma progression
Molecular Oncology, EarlyView.Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen +5 more
wiley +1 more source
Pade-Type Model Reduction of Second-Order and Higher-Order Linear Dynamical Systems
, 2004 A standard approach to reduced-order modeling of higher-order linear dynamical systems is to rewrite the system as an equivalent first-order system and then employ Krylov-subspace techniques for reduced-order modeling of first-order systems.
Freund, Roland W.
core
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Model Order Reduction Methods for Rotating Electrical Machines: A Review
EnergiesDue to the rise of e-mobility applications, there is an increased demand to create more accurate control methods, which can reduce the loss in an e-drive system.
Kristóf Levente Kiss, Tamás Orosz
doaj +1 more source
Model order reduction of flow based on a modular geometrical approximation of blood vessels. [PDF]
Comput Methods Appl Mech Eng, 2021 Pegolotti L +3 more
europepmc +1 more source