Results 101 to 110 of about 1,373,381 (258)

Model Order Reduction Methods for Rotating Electrical Machines: A Review

open access: yesEnergies
Due to the rise of e-mobility applications, there is an increased demand to create more accurate control methods, which can reduce the loss in an e-drive system.
Kristóf Levente Kiss, Tamás Orosz
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Model Order Reduction of Vehicle Air-Conditioning Loop with Neural Networks

open access: yesEngineering Perspective
To meet the energy demand, passenger’s comfort and sustainability in the air conditioning system of vehicles, the Neural Network plays an intelligent role. In this study, the vehicle air conditioning loop was replaced with the reduced control model using
Dr. Shıvakumar Nagareddy   +3 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

open access: yesFEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt   +8 more
wiley   +1 more source

A Forecast Test for Reducing Dynamical Dimensionality of Model Emulators

open access: yesJournal of Advances in Modeling Earth Systems
The climate system can be numerically represented by a set of physically based dynamical equations whose solution requires substantial computational resources.
Tongtong Xu   +3 more
doaj   +1 more source

Model-Order Reduction of Multistage Cascaded Models for Digital Predistortion

open access: yesIEEE Journal of Microwaves
This paper explores the benefits of utilizing multistage cascaded (CC) behavioral models for digital predistortion (DPD) linearization of wideband high-efficiency power amplifiers (PAs).
Raul Criado   +5 more
doaj   +1 more source

Model Order Reduction for Modeling the Brain

open access: yes, 2023
In this thesis, we study the use of Model Order Reduction (MOR) methods for accelerating and reducing the computational burden of brain simulations. Mathematical modeling and numerical simulations are the primary tools of computational neuroscience, a field that strives to understand the brain by combining data and theories.
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

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