Results 131 to 140 of about 24,860,274 (294)

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Model Order Reduction for Modeling the Brain

, 2023
In this thesis, we study the use of Model Order Reduction (MOR) methods for accelerating and reducing the computational burden of brain simulations. Mathematical modeling and numerical simulations are the primary tools of computational neuroscience, a field that strives to understand the brain by combining data and theories.
openaire   +2 more sources

Model-Order Reduction of Multistage Cascaded Models for Digital Predistortion

IEEE Journal of Microwaves
This paper explores the benefits of utilizing multistage cascaded (CC) behavioral models for digital predistortion (DPD) linearization of wideband high-efficiency power amplifiers (PAs).
Raul Criado, Wantao Li, William Thompson, Gabriel Montoro, Kevin Chuang, Pere L. Gilabert   +5 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Interpolation Based Parametric Model Order Reduction [PDF]

, 2012
In this thesis, we consider model order reduction of parameter-dependent large-scale dynamical systems. The objective is to develop a methodology to reduce the order of the model and simultaneously preserve the dependence of the model on parameters.
Nguyen, Thanh Son
core  

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Modeling of fractional-order integrators and differentiators using Tustin-based approximations and model order reduction techniques

, 2018
<p>Low-order approximators of fractional-order derivative and integrator</p> <p>This archive contains the Matlab scripts to calculate low-order approximator of fractional-order derivative and integrator. The approximator&
Rafał Stanisławski (4843203), Marek Rydel (4843194), Marcin Gałek (5401646), Marek Rydel, Marcin Gałek, Rafał Stanisławski   +5 more
core   +1 more source

A Forecast Test for Reducing Dynamical Dimensionality of Model Emulators

Journal of Advances in Modeling Earth Systems
The climate system can be numerically represented by a set of physically based dynamical equations whose solution requires substantial computational resources.
Tongtong Xu, Matthew Newman, Michael A. Alexander, Antonietta Capotondi   +3 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source