Results 151 to 160 of about 715,052 (314)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Model Predictive Control of Underwater Tethered Payload

Applied Sciences
A fully automated, buoy-based deployment sensor system is being developed to acquire high-quality water column data, and requires a controller to accurately position an array of sensors at various depths.
Mark O’Connor, Andy Simoneau, Rickey Dubay   +2 more
doaj   +1 more source

Non-linear predictive control for manufacturing and robotic applications

, 2001
The paper discusses predictive control algorithms in the context of applications to robotics and manufacturing systems. Special features of such systems, as compared to traditional process control applications, require that the algorithms are capable of ...
Grimble, M.J., Ordys, A.W.
core  

On the Stability of Nonlinear Model Predictive Control for 3D Target Tracking [PDF]

In this study, we present the stability analysis of a Nonlinear Model Predictive Control (NMPC) of a 3D ground target tracking system model. The system model is derived considering the 3D kinematic system model referenced to the ground target.
Ha, QP, Torres, IJ, Aguilera, RP
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Deep Operator Neural Network Model Predictive Control

IEEE Open Journal of Control Systems
In this paper, we consider the design of model predictive control (MPC) algorithms based on deep operator neural networks (DeepONets) (Lu et al. 2021).
Thomas O. de Jong, Khemraj Shukla, Mircea Lazar   +2 more
doaj   +1 more source

Polynomial approach to nonlinear predictive generalized minimum variance control

, 2010
A relatively simple approach to non-linear predictive generalised minimum variance (NPGMV) control is introduced for non-linear discrete-time multivariable systems.
Majecki, P.M., Grimble, M.J.
core   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Bisimulation metric for Model Predictive Control

CoRR
Model-based reinforcement learning has shown promise for improving sample efficiency and decision-making in complex environments. However, existing methods face challenges in training stability, robustness to noise, and computational efficiency. In this paper, we propose Bisimulation Metric for Model Predictive Control (BS-MPC), a novel approach that ...
Yutaka Shimizu, Masayoshi Tomizuka
openaire   +3 more sources

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source