Results 101 to 110 of about 32,991,499 (363)

The Role of Scientists in Risk Assessment [PDF]

, 1990
The authors argue that Risk assessors belong to a profession and offer an alternative to the 1983 National Research Council model defining Risk assessment.
Brown, Halina Szejwald, Goble, Robert L.
core   +1 more source

Measuring Model Risk [PDF]

, 2013
We propose to interpret distribution model risk as sensitivity of expected loss to changes in the risk factor distribution, and to measure the distribution model risk of a portfolio by the maximum expected loss over a set of plausible distributions defined in terms of some divergence from an estimated distribution.
Thomas Breuer, Imre Csiszar
openaire   +2 more sources

BOADICEA: a comprehensive breast cancer risk prediction model incorporating genetic and nongenetic risk factors

Genetics in Medicine, 2019
Breast cancer (BC) risk prediction allows systematic identification of individuals at highest and lowest risk. We extend the Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm (BOADICEA) risk model to incorporate the ...
Andrew Lee, N. Mavaddat, A. Wilcox, A. Cunningham, T. Carver, Simon Hartley, Chantal Babb de Villiers, A. Izquierdo, J. Simard, M. Schmidt, F. Walter, N. Chatterjee, M. García-Closas, M. Tischkowitz, P. Pharoah, D. Easton, A. Antoniou   +16 more
semanticscholar   +1 more source

Clinical applications of next‐generation sequencing‐based ctDNA analyses in breast cancer: defining treatment targets and dynamic changes during disease progression

Molecular Oncology, EarlyView.
Circulating tumor DNA (ctDNA) offers a possibility for different applications in early and late stage breast cancer management. In early breast cancer tumor informed approaches are increasingly used for detecting molecular residual disease (MRD) and early recurrence. In advanced stage, ctDNA provides a possibility for monitoring disease progression and
Eva Valentina Klocker, Samantha Hasenleithner, Rupert Bartsch, Simon P. Gampenrieder, Daniel Egle, Christian F. Singer, Gabriel Rinnerthaler, Michael Hubalek, Katja Schmitz, Zsuzsanna Bago‐Horvath, Andreas Petzer, Sonja Heibl, Ellen Heitzer, Marija Balic, Michael Gnant   +14 more
wiley   +1 more source

Cyber loss model risk translates to premium mispricing and risk sensitivity. [PDF]

Geneva Pap Risk Insur Issues Pract, 2023
Peters GW, Malavasi M, Sofronov G, Shevchenko PV, Trück S, Jang J.   +5 more
europepmc   +1 more source

Characteristics Are Covariances: A Unified Model of Risk and Return

Journal of Financial Economics, 2018
We propose a new modeling approach for the cross section of returns. Our method, Instrumented Principal Components Analysis (IPCA), allows for latent factors and time-varying loadings by introducing observable characteristics that instrument for the ...
B. Kelly, Seth Pruitt, Yi-Kai Su
semanticscholar   +1 more source

Circulating tumor cells in metastatic breast cancer patients treated with immune checkpoint inhibitors – a biomarker analysis of the ALICE and ICON trials

Molecular Oncology, EarlyView.
In this explorative biomarker analysis, we assessed serial sampling of circulating tumor cells (CTCs) with CellSearch in two randomized trials testing immune checkpoint inhibitors (ICIs) in metastatic breast cancer. Our data demonstrate a prognostic potential of CTCs, most apparent 4 weeks into ICI therapy.
Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Elin Borgen, Cecilie Bendigtsen Schirmer, Bjørnar Gilje, Øystein Garred, Jon Lømo, Marius Stensland, Oddmund Nordgård, Ragnhild Sørum Falk, Randi R. Mathiesen, Hege G. Russnes, Jon Amund Kyte, Bjørn Naume   +13 more
wiley   +1 more source

On a Multiplicative Multivariate Gamma Distribution with Applications in Insurance

Risks, 2018
One way to formulate a multivariate probability distribution with dependent univariate margins distributed gamma is by using the closure under convolutions property.
Vadim Semenikhine, Edward Furman, Jianxi Su   +2 more
doaj   +1 more source

Prediction Model Risk-of-Bias Assessment Tool for coronary artery lesions in Kawasaki disease. [PDF]

Front Cardiovasc Med, 2022
Huang H, Dong J, Wang S, Shen Y, Zheng Y, Jiang J, Zeng B, Li X, Yang F, Ma S, He Y, Lin F, Chen C, Chen Q, Lv H.   +14 more
europepmc   +1 more source

Model Risk and Its Control [PDF]

In this paper, we analyze model risks separately in pricing models and risk measurement models as follows. (1) In pricing models, model risk is defined as "the risk arising from the use of a model which cannot accurately evaluate market prices, or which ...
Kato, Toshiyasu, Yoshiba, Toshinao
core