Results 101 to 110 of about 3,666,543 (317)

Cyber loss model risk translates to premium mispricing and risk sensitivity. [PDF]

Geneva Pap Risk Insur Issues Pract, 2023
Peters GW, Malavasi M, Sofronov G, Shevchenko PV, Trück S, Jang J.   +5 more
europepmc   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

On long-term credit risk assessment and rating : Towards a new set of models [PDF]

, 2009
Technical ReportInstitutional investors are supposed to assess credit risk by using a combination of quantitative information such as option models and qualitative assessments.
Kubo, Hideya, Sakai, Yasuhiro
core  

A risk model for indoor environment safety [PDF]

, 2017
Indoor environment could be hazardous to occupants, so hazard information for detection, prediction and reaction becomes necessary. In order to provide comprehensive hazard information, this research proposed the concept of Performers System with the ...
Yang, Zhengguo, Zhengguo Yang, Yuto Lim, Tan, Yasuo, Yasuo Tan, Lim, Yuto   +5 more
core   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Prediction Model Risk-of-Bias Assessment Tool for coronary artery lesions in Kawasaki disease. [PDF]

Front Cardiovasc Med, 2022
Huang H, Dong J, Wang S, Shen Y, Zheng Y, Jiang J, Zeng B, Li X, Yang F, Ma S, He Y, Lin F, Chen C, Chen Q, Lv H.   +14 more
europepmc   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Using the Prediction Model Risk of Bias Assessment Tool (PROBAST) to Evaluate Melanoma Prediction Studies. [PDF]

Cancers (Basel), 2022
Kaiser I, Mathes S, Pfahlberg AB, Uter W, Berking C, Heppt MV, Steeb T, Diehl K, Gefeller O.   +8 more
europepmc   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Health Behaviours in Scaffold Use Risk Assessment Model – SURAM

Annals of Agricultural and Environmental Medicine, 2019
Introduction Problems concerning occupational safety and health are commonly found in the construction industry, including falling materials, tools or people from a height, stepping on objects, and injuries caused by hand tools.
Hubert Bojar, Francisco Silveira, Mario Rebelo, Czarnocka Elżbieta, Czarnocki Krzysztof   +4 more
doaj   +1 more source