Results 81 to 90 of about 2,501,945 (313)
ABSTRACT Background Maintenance hemodialysis (MHD) patients frequently suffer from frailty, characterized by reduced physical function and poor prognosis. Myokines, such as myonectin, secreted by muscle, are emerging regulators of systemic health. This study investigated the relationship between serum myonectin, adipokines (adiponectin, omentin), and ...
Kenichi Kono +7 more
wiley +1 more source
Summary Many popular methods of model selection involve minimizing a penalized function of the data (such as the maximized log‐likelihood or the residual sum of squares) over a set of models. The penalty in the criterion function is controlled by a penalty multiplier λ which determines the properties of the procedure.
Muller, Samuel, Welsh, Alan
openaire +3 more sources
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo +5 more
wiley +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
A new hybrid supplier selection model
Selecting the right supplier is one of the most challenging tasks for organisations as it essentially reduces purchasing cost and improves corporate competitiveness. This study aims at developing a hybrid model in supplier selection for a non-homogeneous
Rahman, A, Nguyen, TS, Mohamed, S
core +1 more source
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Model selection in supervised classification [PDF]
This article is concerned with the selection of a generative model for supervised classification. Classical model selection criteria are assessing the fit of a model rather than its ability to produce a low classification error rate. A new criterion, the
Bouchard, Guillaume, Celeux, Gilles
core +1 more source
Variance Estimates and Model Selection [PDF]
The large majority of the criteria for model selection are functions of the usual variance estimate for a regression model. The validity of the usual variance estimate depends on some assumptions, most critically the validity of the model being estimated.
Sýdýka Baþçý +2 more
core
Regularization and Model Selection with Categorial Effect Modifiers [PDF]
The case of continuous effect modifiers in varying-coefficient models has been well investigated. Categorial effect modifiers, however, have been largely neglected.
Gertheiss, Jan, Tutz, Gerhard
core +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source

