Results 111 to 120 of about 5,324,413 (319)

Research on Excavation Method for Soft Rock Tunnel Based on Stress Release Rate

open access: yesApplied Sciences
A test method for controlling the stress release rate of the tunnel by adjusting the confining pressure is proposed based on the engineering background of Dongmachang No.
Jincheng Nie   +4 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

On changing models in model-based testing [PDF]

open access: yes, 2011
action LaserStatus !callLaserStatus ?getLaserStatus r(LaserStatus) !callLaserStatus r(LaserStatus) ?getLaserStatus ?other Figure 4.9: Remote procedure ...
openaire   +1 more source

Thermal-Safe Test Scheduling for Core-Based System-on-a-Chip Integrated Circuits

open access: yes, 2005
Overheating has been acknowledged as a major problem during the testing of complex system-on-chip (SOC) integrated circuits. Several power-constrained test scheduling solutions have been recently proposed to tackle this problem during system integration.
Rosinger, Paul   +2 more
core  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Sustainable Business Administration Knowledge Test

open access: yes, 2019
Der NaWi-Test ist ein standardisierter Test zur Erfassung des Fachwissens über nachhaltiges Wirtschaften von Auszubildenden, Schülerinnen und Schülern, Lehrkräften sowie Beschäftigten in Unternehmen. Er umfasst 15 empirisch geprüfte Aufgaben, die jeweils
Heubischl, S.   +5 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Synchronization Overhead in SOC Compressed Test

open access: yes, 2005
Test data compression is an enabling technology for low-cost test. Compression schemes however, require communication between the system under test and the automated test equipment.
Gonciari, Paul Theo   +2 more
core  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

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