Results 121 to 130 of about 11,903,474 (342)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Experimental and numerical study on temperature field by freezing pipe of double chambers

矿业科学学报, 2016
In order to control the horizontal energy transfer of freezing pipe, a new type freezing pipe with two chambers was set up.The temperature field of this new freezing pipe was analyzed by model test and numerical simulation.The results show that the ...
Sun Qiang, Yang Liyun, Chen Jun, Wang Qianxing, Liu Ju   +4 more
doaj  

Research on the Calculation Method of Internal Force of Fully Buried Double-Row Skid Piles Based on Tests

Applied Sciences
In order to discuss the calculation model and design method of double-row sliding piles without a connected beam, a laboratory simulation test was carried out.
Xunchang Li, Zhengzheng Shi, Fanfan Gao, Dongdong Han   +3 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Study on the horizontal bearing mechanism of stepped variable cross-section piles

河南理工大学学报. 自然科学版
ObjectivesThis study aims to investigate the horizontal bearing mechanism of rigid and elastic stepped variable cross-section piles in silty sand foundations and to evaluate the impact of variable diameter factors on horizontal bearing capacity.
ZHANG Jianwei, YANG Sen, YU Lu, HE Shanlin, ZHANG Yan   +4 more
doaj   +1 more source

Parameterisation of the Koppejan settlement prediction model using cone penetration testing and gradient boosting [PDF]

, 2020
Kevin Duffy, Klaas Siderius, Michael Long   +2 more
openalex   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Experimental Study on Tunnel Failure Mechanism and the Effect of Combined Anti-Dislocation Measures Under Fault Dislocation

Applied Sciences
Taking the tunnels crossing active faults in China’s Sichuan–Tibet Railway as the research background, experimental studies were conducted using a custom-developed split model box.
Jiaxuan Du, Songhong Yan, Weiyu Sun, Mingxing Cao, Yuxiang Li   +4 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source