Results 121 to 130 of about 11,765,211 (293)

Study on the horizontal bearing mechanism of stepped variable cross-section piles

open access: yes河南理工大学学报. 自然科学版
ObjectivesThis study aims to investigate the horizontal bearing mechanism of rigid and elastic stepped variable cross-section piles in silty sand foundations and to evaluate the impact of variable diameter factors on horizontal bearing capacity.
ZHANG Jianwei   +4 more
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

open access: yesFEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Experimental Study on Tunnel Failure Mechanism and the Effect of Combined Anti-Dislocation Measures Under Fault Dislocation

open access: yesApplied Sciences
Taking the tunnels crossing active faults in China’s Sichuan–Tibet Railway as the research background, experimental studies were conducted using a custom-developed split model box.
Jiaxuan Du   +4 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

open access: yesFEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang   +9 more
wiley   +1 more source

Numerical Research on Hull–Propeller–Rudder–Ice Interaction of Full-Scale Polar Transport Ship in Brash Ice Channel

open access: yesJournal of Marine Science and Engineering
A strong nonlinear ice load has a significant impact on the resistance and power demand of polar transport ships under different drafts in brash ice channels.
Jinlong Zhang   +4 more
doaj   +1 more source

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