Results 161 to 170 of about 11,765,211 (293)
Filtering Test Models to Support Incremental Testing
, 2010 Model-based testing can be hampered by the fact that a model depicting the system as designed does not necessarily correspond to the product as it is during development. Tests generated from such a model may be impossible to execute due to unimplemented features and already known errors. This paper presents a solution in which parts of the model can be
openaire +2 more sources
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Investigation of Deformation Pattern and Movement Law of the Huge-Thick Conglomerate Stratum by a Large-Scale 3D Model Test with Distributed Optical Fiber Sensor Monitoring. [PDF]
Sensors (Basel), 2021 Yuan Q, Chai J, Zhang Y, Liu Y, Ren Y.
europepmc +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
The Mediating Effect of Marital Intimacy on the Relationship between Spouse-Related Stress and Prenatal Depression in Pregnant Couples: An Actor-Partner Interdependent Model Test. [PDF]
Int J Environ Res Public Health, 2021 Lee M, Kim YS, Lee MK.
europepmc +1 more source
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Research on ground pressure control modes in a subsea mine by physical model test and numerical simulation analysis. [PDF]
Sci RepLiu W, Liu Z, Qiu J, Guo T, Zhu Q.
europepmc +1 more source
Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source
Seepage of aging conduits in small reservoirs by centrifuge model test. [PDF]
Sci RepJin J, Lee S.
europepmc +1 more source