Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Failure mechanism of a loess slope under extreme rainfall through a model test study of Shixiakou, Lanzhou. [PDF]
Li Y +7 more
europepmc +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Physical model test on the effect of geosynthetic reinforcement on embankment constructed with modified lateritic soil under wetting-vibration. [PDF]
Han X, Gong J, He H, Yang G.
europepmc +1 more source
Investigation of Deformation Pattern and Movement Law of the Huge-Thick Conglomerate Stratum by a Large-Scale 3D Model Test with Distributed Optical Fiber Sensor Monitoring. [PDF]
Yuan Q, Chai J, Zhang Y, Liu Y, Ren Y.
europepmc +1 more source
Test-retest reliability of iTBS and metaplasticity potential: insight from a non-human primate model
Colleen A. Hanlon +5 more
openalex +1 more source
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Research on ground pressure control modes in a subsea mine by physical model test and numerical simulation analysis. [PDF]
Liu W, Liu Z, Qiu J, Guo T, Zhu Q.
europepmc +1 more source

