Results 91 to 100 of about 7,641,165 (285)
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
The “Academic Literacies” Model: Theory and Applications
Filologia e Linguística Portuguesa, 2014 Although the term academic literacies was originally developed with regard to the study of literacies in higher education and the university, the concept also applies to K–12 education.
Fabiana Cristina Komesu +1 more
doaj +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Contextual measurement model and quantum theory
Royal Society Open ScienceWe develop a contextual measurement model (CMM) that is used for the clarification of the quantum foundations. This model matches Bohr’s views on the role of experimental contexts.
Andrei Khrennikov
doaj +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Evidential Statistics in Model and Theory Development
Frontiers in Ecology and Evolution, 2019 Evidential statistics is an important advance in model and theory testing, and scientific reasoning in general, combining and extending key insights from other philosophies of statistics.
Samuel M. Scheiner, Robert D. Holt
doaj +1 more source
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
Minimal Pati-Salam Model from String Theory Unification
, 2007 We provide what we believe is the minimal three family ${\cal N} = 1$ SUSY and conformal Pati-Salam Model from type IIB superstring theory. This $Z_3$ orbifolded AdS$\otimes S^5$ model has long lived protons and has potential phenomenological ...
James B. Dent +2 more
core +1 more source
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
Computer-animated model of accommodation and theory of reciprocal zonular action
Clinical Ophthalmology, 2011 Daniel B Goldberg1,2 1Ophthalmology Department, Drexel College of Medicine, Philadelphia, PA, 2Eye Physicians, Little Silver, NJ, USA Abstract: This report presents a computer-animated model of the structures of accommodation based on new understanding ...
Goldberg DB
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