Results 91 to 100 of about 24,109,276 (315)

Model-Driven Development of Model Transformations [PDF]

, 2008
This thesis presents how evolving software models expressed in different formalisms can be kept consistent by means of an object-oriented integration of metamodeling, design by contract and graph transformation. It incrementally builds upon existing modeling languages to illustrate that the adoption of the new model-driven engineering paradigm does not
openaire   +3 more sources

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

TRANSFORMACIÓN DE ESQUEMAS MULTIDIMENSIONALES DIFUSOS DESDE EL NIVEL CONCEPTUAL AL NIVEL LÓGICO FUZZY MULTIDIMENSIONAL SCHEMA TRANSFORMATION FROM CONCEPTUAL TO LOGICAL LEVEL

Ingeniare: Revista Chilena de Ingeniería, 2010
En el ámbito de las bases de datos, diversos métodos han sido propuestos para la generación del diseño lógico de un almacén de datos o data warehouse (DW), por otra parte, existen estudios que permiten el almacenamiento y operación de datos imprecisos o ...
Sabina Carrera Sepúlveda, Marcela Varas Contreras, Angélica Urrutia Sepúlveda   +2 more
doaj  

CSIMQ Anniversary Editor-in-Chief Thoughts and Editorial Introduction to Issue 38: Model-based and Decision Support Methods for Next-generation Information Systems

Complex Systems Informatics and Modeling Quarterly
The 38th issue of CSIMQ comprises four articles selected by guest issue editors on topics related to novel decision support methods or model-based frameworks for evolving or evaluating information systems.
Anders Flodström, Robert Andrei Buchmann, Andrea Morichetta   +2 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Model Transformations Used in IT Project Initial Phases: Systematic Literature Review

Computers
The paper emphasizes the critical importance of the initial phase in IT project development to avoid implementation errors. It argues that minimizing these errors can be achieved by developing project artifacts at the early stage using a model-driven ...
Oksana Nikiforova, Kristaps Babris, Uldis Karlovs-Karlovskis, Marta Narigina, Andrejs Romanovs, Anita Jansone, Janis Grabis, Oscar Pastor   +7 more
doaj   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Translation Of Use Case Scenarios To Java Code

Computer Science, 2012
Use cases are usually treated as second class citizens in the software developmentchain based on models. Their textual descriptions (scenarios) are treatedas informal input to more formal design models that can then be (semi-)automatically transformed ...
Michał Smialek, Norbert Jarzebowski, Wiktor Nowakowski   +2 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source