Results 91 to 100 of about 3,690,239 (301)

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

UML Sequence Diagram: Transformation from the Two-Hemisphere Model and Layout

Applied Computer Systems, 2013
Modeling of the object interaction is one of the core tasks during system analysis and design, because it gives developer an ability to define responsibilities of class objects and to sketch general architecture of software components.
Nikiforova Oksana, Kozacenko Ludmila, Ahilcenoka Dace   +2 more
doaj   +1 more source

The Darboux-Backlund transformation for the static 2-dimensional continuum Heisenberg chain

, 2006
We construct the Darboux-Backlund transformation for the sigma model describing static configurations of the 2-dimensional classical continuum Heisenberg chain.
Belavin A A, Bobenko A I, Błaszak M, Cieśliński J, Cieśliński J L, Cieśliński J Sym A, Doliwa A Sym A Boiti M Martina L Pempinelli L, Jan L Cieśliński, Joanna Czarnecka, Khare A, Leese R A, Novikov S P, Zakharov V E   +12 more
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

The Knowledge Frame System based on Principles of Topological Functioning Model

Applied Computer Systems, 2017
Understanding of domain phenomena and their interrelations is necessary for successful software development. The knowledge frame system based on principles of Topological Functioning Modelling (TFM) can be used for this purpose at the Computation ...
Nazaruks Vladislavs
doaj   +1 more source

Hierarchical Verification for the BPMN Design Model Using State Space Analysis

IEEE Access, 2019
The BPMN design models are widely used in the software development process. Owing to the lack of BPMN standard semantics, formal verification is used to validate whether the BPMN design model is free of undesirable properties.
C. Dechsupa, W. Vatanawood, A. Thongtak
doaj   +1 more source

Heteroscedastic semiparametric transformation models: estimation and testing for validity [PDF]

, 2014
In this paper we consider a heteroscedastic transformation model, where the transformation belongs to a parametric family of monotone transformations, the regression and variance function are modelled nonparametrically and the error is independent of the
Neumeyer, Natalie, Noh, Hohsuk, Van Keilegom, Ingrid   +2 more
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Applying Model Driven Engineering Techniques and Tools to the Planets Game Learning Scenario

Journal of Interactive Media in Education, 2007
CPM (Cooperative Problem-Based learning Metamodel) is a visual language for the instructional design of Problem-Based Learning (PBL) situations. This language is a UML profile implemented on top of the Objecteering UML Case tool.
Thierry Nodenot, Pierre André Caron, Xavier Le Pallec, Pierre Laforcade   +3 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source