Results 81 to 90 of about 1,058,068 (314)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Ontology transformation and reasoning for model-driven architecture [PDF]
, 2005 Model-driven Architecture (MDA) is a software architecture framework proposed by the Object Management Group OMG. MDA emphasises the importance of modelling in the architectural design of service-based software systems.
Claus Pahl, Pahl, Claus
core +1 more source
Revista EIA, 2008 Actualmente en los ambientes de desarrollo de software hay un gran interés en buscar y desarrollar técnicas que puedan integrar los sistemas transaccionales con los flujos de trabajo que soportan los procesos del negocio de las organizaciones.
Marta Silvia Tabares +2 more
doaj
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Language Models with Transformers
CoRR, 2019 The Transformer architecture is superior to RNN-based models in computational efficiency. Recently, GPT and BERT demonstrate the efficacy of Transformer models on various NLP tasks using pre-trained language models on large-scale corpora. Surprisingly, these Transformer architectures are suboptimal for language model itself.
Chenguang Wang 0001 +2 more
openaire +2 more sources
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Model Transformation: A Declarative, Reusable Patterns Approach [PDF]
, 2003 The MOF Query, View and Transformation RFP, issued by OMG will result in a key enabling technology for model-driven development of large distributed systems.
Keith Duddy +14 more
core +1 more source
Translation Of Use Case Scenarios To Java Code
Computer Science, 2012 Use cases are usually treated as second class citizens in the software developmentchain based on models. Their textual descriptions (scenarios) are treatedas informal input to more formal design models that can then be (semi-)automatically transformed ...
Michał Smialek +2 more
doaj +1 more source
Graphical Transformation Models
CoRR36 pages, 10 Figures, presented at the DAGStat 2025 in Berlin initially submitted to the Journal of Computational and Graphical ...
Matthias Herp +3 more
openaire +2 more sources