Results 61 to 70 of about 15,140,590 (208)
The Evaluation of Secondary Schools in Jamaica A Value-Added Approach [PDF]
, 2021 This policy brief summarizes the new value-added method for evaluating Jamaica’s schools, explains the composite value-added measure derived from it, and presents the findings of the first complete application of the method to the evaluation of the ...
Jamaica Education Transformation Commission
core
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Formal foundations for software model to model transformation operation [PDF]
, 2018 Software model transformation operations are central operations in Model-Driven approaches. In order to represent software models, graphical modeling notations, for example UML, are used.
Chebanyuk, O.V.
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EnergiesIn order to fully utilize the control degrees of freedom of a multi-three-phase-star smooth-pole permanent magnet synchronous motor (PMSM), this paper first develops a modeling approach using a new matrix transformation method.
Shu Mo +4 more
doaj +1 more source
Applied Computer Systems, 2014 The software system needs to be analyzed and designed before the program code is written. A Computation Independent Model (CIM) and a Platform Independent Model/ Platform Specific Model (PIM/PSM) from Model-Driven Architecture (MDA) will be partially ...
Ovchinnikova Viktoria +2 more
doaj +1 more source
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
Incremental model transformation for the evolution of model-driven systems [PDF]
, 2006 Model transformations are an integral part of model-driven development. Incremental updates are a key execution scenario for transformations in model-based systems, and are especially important for the evolution of such systems.
Michael Lawley +5 more
core +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source