Results 71 to 80 of about 1,058,068 (314)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
IEEE AccessModel-driven development (MDD) in the Artificial Intelligence of Things (AIoT) domain faces significant challenges in ensuring the consistency and preservation of model properties during transformations, often leading to system inconsistencies.
Gullelala Jadoon +6 more
doaj +1 more source
Transforming BPMN Processes to SBVR Process Rules with Deontic Modalities
Applied Sciences, 2022 The Object Management Group (OMG) has put considerable effort into the standardization of various business modeling aspects within the context of model-driven systems development. Indeed, the Business Process Model and Notation (BPMN) is now arguably the
Tomas Skersys +3 more
doaj +1 more source
Conditional Transformation Models [PDF]
Journal of the Royal Statistical Society Series B: Statistical Methodology, 2013 SummaryThe ultimate goal of regression analysis is to obtain information about the conditional distribution of a response given a set of explanatory variables. This goal is, however, seldom achieved because most established regression models estimate only the conditional mean as a function of the explanatory variables and assume that higher moments are
Hothorn, Torsten +2 more
openaire +5 more sources
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Formal foundations for software model to model transformation operation [PDF]
, 2018 Software model transformation operations are central operations in Model-Driven approaches. In order to represent software models, graphical modeling notations, for example UML, are used.
Chebanyuk, O.V.
core
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Designing an intelligent Business Model Transformation Tool [PDF]
, 2017 Global companies as well as small and medium-sized businesses have to respond to fast-changing markets and new customer demands to maintain their position in competition.
Augenstein, Dominik
core +1 more source
Dynamically Integrating OSM Data into a Borderland Database
ISPRS International Journal of Geo-Information, 2015 Spatial data are fundamental for borderland analyses of geography, natural resources, demography, politics, economy, and culture. As the spatial data used in borderland research usually cover the borderland regions of several neighboring countries, it is
Xiaoguang Zhou +4 more
doaj +1 more source
Anemic Domain Model vs Rich Domain Model to Improve the Two-Hemisphere Model-Driven Approach
Applied Computer Systems, 2020 Evolution of software development process and increasing complexity of software systems calls for developers to pay great attention to the evolution of CASE tools for software development.
Nikiforova Oksana, Gusarovs Konstantins
doaj +1 more source