Results 91 to 100 of about 858,963 (269)

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Developing Programs for Converting MIDAS GEN to ANSYS Models Based on Python

Buildings
The reasonableness and accuracy of engineering design are often assessed through the use of a variety of structural design analysis software, which are then compared and verified.
Yuqing Yang, Fanchang Kong, Zhelong Jiang, Zaigen Mu   +3 more
doaj   +1 more source

UML Sequence Diagram: Transformation from the Two-Hemisphere Model and Layout

Applied Computer Systems, 2013
Modeling of the object interaction is one of the core tasks during system analysis and design, because it gives developer an ability to define responsibilities of class objects and to sketch general architecture of software components.
Nikiforova Oksana, Kozacenko Ludmila, Ahilcenoka Dace   +2 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Towards an effective approach for composition of model transformations

Frontiers in Computer Science
Model Driven Engineering (MDE) adoption in the industry suffers from many technical and non-technical problems. One of the significant technical problems lies in the difficulty of building complex transformations from the composition of small and ...
Hamza Abdelmalek, Ismaïl Khriss, Abdeslam Jakimi   +2 more
doaj   +1 more source

The Knowledge Frame System based on Principles of Topological Functioning Model

Applied Computer Systems, 2017
Understanding of domain phenomena and their interrelations is necessary for successful software development. The knowledge frame system based on principles of Topological Functioning Modelling (TFM) can be used for this purpose at the Computation ...
Nazaruks Vladislavs
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

A Dual-Stage Framework for Behavior-Enhanced Automated Code Generation in Industrial-Scale Meta-Models

IEEE Access
Industrial model-driven engineering often struggles to generate functionally complete code, especially dynamic behaviors, from large-scale Meta-models, typically yielding only static structures.
Tong Ma, Shenlong Dai, Yongfan Gao, Fengjie Xu, Ling Fang   +4 more
doaj   +1 more source

Model transformations in Converge [PDF]

Model transformations are currently the focus of much interest and research due to the OMG’s QVT initiative. Current proposals for model transformation languages\ud can be divided into two main camps: those taking a ‘declarative’ approach, and those opting for an ‘imperative’ approach.
Tratt, Laurence, Clark, Tony
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