Results 91 to 100 of about 886,399 (267)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Developing Programs for Converting MIDAS GEN to ANSYS Models Based on Python

Buildings
The reasonableness and accuracy of engineering design are often assessed through the use of a variety of structural design analysis software, which are then compared and verified.
Yuqing Yang, Fanchang Kong, Zhelong Jiang, Zaigen Mu   +3 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Towards an effective approach for composition of model transformations

Frontiers in Computer Science
Model Driven Engineering (MDE) adoption in the industry suffers from many technical and non-technical problems. One of the significant technical problems lies in the difficulty of building complex transformations from the composition of small and ...
Hamza Abdelmalek, Ismaïl Khriss, Abdeslam Jakimi   +2 more
doaj   +1 more source

UML Sequence Diagram: Transformation from the Two-Hemisphere Model and Layout

Applied Computer Systems, 2013
Modeling of the object interaction is one of the core tasks during system analysis and design, because it gives developer an ability to define responsibilities of class objects and to sketch general architecture of software components.
Nikiforova Oksana, Kozacenko Ludmila, Ahilcenoka Dace   +2 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

A Dual-Stage Framework for Behavior-Enhanced Automated Code Generation in Industrial-Scale Meta-Models

IEEE Access
Industrial model-driven engineering often struggles to generate functionally complete code, especially dynamic behaviors, from large-scale Meta-models, typically yielding only static structures.
Tong Ma, Shenlong Dai, Yongfan Gao, Fengjie Xu, Ling Fang   +4 more
doaj   +1 more source

The Knowledge Frame System based on Principles of Topological Functioning Model

Applied Computer Systems, 2017
Understanding of domain phenomena and their interrelations is necessary for successful software development. The knowledge frame system based on principles of Topological Functioning Modelling (TFM) can be used for this purpose at the Computation ...
Nazaruks Vladislavs
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source