Results 101 to 110 of about 3,690,239 (301)
Complex Systems Informatics and Modeling Quarterly, 2017 System thinking has become an effective strategy when dealing with complex systems. Such systems are characterized by mutual interactions, causality and inter-dependency between system components. A typical example is the cooperation between governmental
Maryam M. Khamis, Theo P. van der Weide
doaj +1 more source
Resource-Bound Quantification for Graph Transformation
, 2010 Graph transformation has been used to model concurrent systems in software engineering, as well as in biochemistry and life sciences. The application of a transformation rule can be characterised algebraically as construction of a double-pushout (DPO ...
A. S. Troelstra +26 more
core +2 more sources
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Workflow Generation from the Two-Hemisphere Model
Applied Computer Systems, 2017 Model-Driven Software Development (MDSD) is a trend in Software Development that focuses on code generation from various kinds of models. To perform such a task, it is necessary to develop an algorithm that performs source model transformation into the ...
Gusarovs Konstantīns +1 more
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Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells
FEBS Letters, EarlyView.Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López +2 more
wiley +1 more source
Using Business Analytics for SME Business Model Transformation under Pandemic Time Pressure. [PDF]
Inf Syst Front, 2022 Zamani ED, Griva A, Conboy K.
europepmc +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Dynamically Integrating OSM Data into a Borderland Database
ISPRS International Journal of Geo-Information, 2015 Spatial data are fundamental for borderland analyses of geography, natural resources, demography, politics, economy, and culture. As the spatial data used in borderland research usually cover the borderland regions of several neighboring countries, it is
Xiaoguang Zhou +4 more
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Anemic Domain Model vs Rich Domain Model to Improve the Two-Hemisphere Model-Driven Approach
Applied Computer Systems, 2020 Evolution of software development process and increasing complexity of software systems calls for developers to pay great attention to the evolution of CASE tools for software development.
Nikiforova Oksana, Gusarovs Konstantins
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