Results 61 to 70 of about 3,014,362 (294)

Mapping the evolution of mitochondrial complex I through structural variation

open access: yesFEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin   +2 more
wiley   +1 more source

Measuring the Uncertainty of Predictions in Deep Neural Networks with Variational Inference

open access: yesSensors, 2020
We present a novel approach for training deep neural networks in a Bayesian way. Compared to other Bayesian deep learning formulations, our approach allows for quantifying the uncertainty in model parameters while only adding very few additional ...
Jan Steinbrener   +2 more
doaj   +1 more source

The Impact of a Regional Nuclear Conflict between India and Pakistan: Two Views

open access: yesJournal for Peace and Nuclear Disarmament, 2021
The severity of climatic effects of a regional nuclear conflict between India and Pakistan, involving the use of a hundred Hiroshima-scale nuclear weapons, is contested between two groups; Mills et al.
G. D. Hess
doaj   +1 more source

Comparison of Deterministic and Probabilistic Variational Data Assimilation Methods Using Snow and Streamflow Data Coupled in HBV Model for Upper Euphrates Basin

open access: yesGeosciences, 2023
The operation of upstream reservoirs in mountainous regions fed by snowmelt is highly challenging. This is partly due to scarce information given harsh topographic conditions and a lack of monitoring stations. In this sense, snow observations from remote
Gökçen Uysal   +3 more
doaj   +1 more source

Generalized entropy and model uncertainty [PDF]

open access: yesJournal of Economic Theory, 2019
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +3 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Improving Re-Identification by Estimating and Utilizing Diverse Uncertainty Types for Embeddings

open access: yesAlgorithms
In most re-identification approaches, embedding vectors are compared to identify the best match for a given query. However, this comparison does not take into account whether the encoded information in the embedding vectors was extracted reliably from ...
Markus Eisenbach   +3 more
doaj   +1 more source

Bayesian Model Averaging and Prior Sensitivity in Stochastic Frontier Analysis

open access: yesEconometrics, 2020
This paper discusses Bayesian model averaging (BMA) in Stochastic Frontier Analysis and investigates inference sensitivity to prior assumptions made about the scale parameter of (in)efficiency. We turn our attention to the “standard” prior specifications
Kamil Makieła, Błażej Mazur
doaj   +1 more source

Probabilistic Models for the Shear Strength of RC Deep Beams

open access: yesApplied Sciences, 2023
A new shear strength determination of reinforced concrete (RC) deep beams was proposed by using a statistical approach. The Bayesian–MCMC (Markov Chain Monte Carlo) method was introduced to establish a new shear prediction model and to improve seven ...
Zhenjun Li   +5 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

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