Results 61 to 70 of about 766,215 (314)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Gas Storage Valuation and Hedging: A Quantification of Model Risk

International Journal of Financial Studies, 2018
This paper focuses on the valuation and hedging of gas storage facilities, using a spot-based valuation framework coupled with a financial hedging strategy implemented with futures contracts. The contributions of this paper are two-fold.
Patrick Hénaff, Ismail Laachir, Francesco Russo   +2 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Trustworthy Super-Resolution of Multispectral Sentinel-2 Imagery With Latent Diffusion

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
Remote sensing super-resolution aims to enhance the spatial details of satellite images by introducing meaningful high-frequency features while avoiding hallucinations and spectral distortions.
Simon Donike, Cesar Aybar, Luis Gomez-Chova, Freddie Kalaitzis   +3 more
doaj   +1 more source

Algorithmic Trading with Model Uncertainty [PDF]

SIAM Journal on Financial Mathematics, 2017
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Álvaro Cartea, Ryan Donnelly, Sebastian Jaimungal   +2 more
openaire   +4 more sources

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Sharp Probability Tail Estimates for Portfolio Credit Risk

Risks, 2022
Portfolio credit risk is often concerned with the tail distribution of the total loss, defined to be the sum of default losses incurred from a collection of individual loans made out to the obligors.
Jeffrey F. Collamore, Hasitha de Silva, Anand N. Vidyashankar   +2 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Characterization of Model Uncertainty for the Vertical Pullout Capacity of Helical Anchors in Cohesive Soils

Journal of Marine Science and Engineering, 2020
This paper conducts coupled Eulerian–Lagrangian (CEL) analysis to characterize the model uncertainty of using the cylindrical shear method (CSM) to predict the pullout capacity of helical anchors in cohesive soils.
Po Cheng, Jiang Tao Yi, Fei Liu, Jun Jie Dong   +3 more
doaj   +1 more source

Model Uncertainty and Selection of Risk Models for Left-Truncated and Right-Censored Loss Data

Risks, 2023
Insurance loss data are usually in the form of left-truncation and right-censoring due to deductibles and policy limits, respectively. This paper investigates the model uncertainty and selection procedure when various parametric models are constructed to
Qian Zhao, Sahadeb Upretee, Daoping Yu
doaj   +1 more source