Results 81 to 90 of about 766,215 (314)
Hands-on MPC Tuning for Industrial Applications [PDF]
Bulletin of the Polish Academy of Sciences: Technical Sciences, 2019 This paper proposes a practical tuning of closed loops with model based predictive control. The data assumed to be known from the process is the result of the bump test commonly applied in industry and known in engineering as step response data.
C. Ionescu, D. Copot
doaj +1 more source
Modelling the Measurement Uncertainty by Intervals
J. Univers. Comput. Sci., 1998 JUCS - Journal of Universal Computer Science Volume Nr.
Wilke,Fabiana +3 more
openaire +2 more sources
, 2009 Probabilistic risk analysis aims to assess the safety risk of a system so that actions can then be taken to improve safety. Uncertainty however always exists in modelling. For more informed decision making, uncertainty in the outputs of the model must be
Cheng, Doasheng, Cheng, Daosheng
core +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Environmental Research Letters, 2018 The impact of grazing activity on terrestrial carbon (C) sequestration has been noticed and studied worldwide. Recent efforts have been made to incorporate the disturbance into process-based land models. However, the performance of grazing models has not
Yizhao Chen +8 more
doaj +1 more source
Model Uncertainty and Monetary Policy [PDF]
SSRN Electronic Journal, 2007 Model uncertainty has the potential to change importantly how monetary policy should be conducted, making it an issue that central banks cannot ignore. In this paper, I use a standard new Keynesian business cycle model to analyze the behavior of a central bank that conducts policy with discretion while fearing that its model is misspeci…ed.
openaire +3 more sources
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Frontiers in Veterinary Science, 2020 In recent years, several generic risk assessment (RA) tools have been developed that can be applied to assess the incursion risk of multiple infectious animal diseases allowing for a rapid response to a variety of newly emerging or re-emerging diseases ...
Clazien J. de Vos +15 more
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Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source