Results 71 to 80 of about 2,973,401 (293)

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Cross-Validation of Generic Risk Assessment Tools for Animal Disease Incursion Based on a Case Study for African Swine Fever

Frontiers in Veterinary Science, 2020
In recent years, several generic risk assessment (RA) tools have been developed that can be applied to assess the incursion risk of multiple infectious animal diseases allowing for a rapid response to a variety of newly emerging or re-emerging diseases ...
Clazien J. de Vos, Rachel A. Taylor, Robin R. L. Simons, Helen Roberts, Cecilia Hultén, Aline A. de Koeijer, Tapani Lyytikäinen, Sebastian Napp, Anette Boklund, Ronald Petie, Kaisa Sörén, Manon Swanenburg, Arianna Comin, Leena Seppä-Lassila, Maria Cabral, Emma L. Snary   +15 more
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Great uncertainties in modeling grazing impact on carbon sequestration: a multi-model inter-comparison in temperate Eurasian Steppe

Environmental Research Letters, 2018
The impact of grazing activity on terrestrial carbon (C) sequestration has been noticed and studied worldwide. Recent efforts have been made to incorporate the disturbance into process-based land models. However, the performance of grazing models has not
Yizhao Chen, Yuwen Tao, Yuan Cheng, Weimin Ju, Jingyi Ye, Thomas Hickler, Cuijuan Liao, Lan Feng, Honghua Ruan   +8 more
doaj   +1 more source

On hedging American options under model uncertainty

, 2015
We consider as given a discrete time financial market with a risky asset and options written on that asset and determine both the sub- and super-hedging prices of an American option in the model independent framework of ArXiv:1305.6008.
Bayraktar, Erhan, Huang, Yu-Jui, Zhou, Zhou   +2 more
core   +1 more source

Model parameter estimation and uncertainty analysis: a report of the ISPOR-SMDM modeling good research practices task force working group - 6 [PDF]

, 2012
A model’s purpose is to inform medical decisions and health care resource allocation. Modelers employ quantitative methods to structure the clinical, epidemiological, and economic evidence base and gain qualitative insight to assist decision makers in ...
Briggs, A.H., Fenwick, E.A.L., Karnon, J., Paltiel, A.D., Sculpher, M.J., Weinstein, M.C.   +5 more
core   +1 more source

Climate model uncertainty versus conceptual geological uncertainty in hydrological modeling [PDF]

Hydrology and Earth System Sciences, 2015
Abstract. Projections of climate change impact are associated with a cascade of uncertainties including in CO2 emission scenarios, climate models, downscaling and impact models. The relative importance of the individual uncertainty sources is expected to depend on several factors including the quantity that is projected.
T. O. Sonnenborg, D. Seifert, J. C. Refsgaard   +2 more
openaire   +3 more sources

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

Uncertainty effect on leak localisation in a DMA [PDF]

, 2016
The leak localisation methodologies based on data and models are affected by both uncertainties in the model and in the measurements. This uncertainty should be quantified so that its effect on the localisation methods performance can be estimated.
Blesa Izquierdo, Joaquim, Cugueró Escofet, Josep, Cugueró Escofet, Miquel Àngel, Pérez Magrané, Ramon, Sanz, Gerard   +4 more
core   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source