Results 111 to 120 of about 35,180,990 (360)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Quantum Modeling

, 2003
We present a modification of Simon's algorithm that in some cases is able to fit experimentally obtained data to appropriately chosen trial functions with high probability.
Goldstein, Darin
core   +1 more source

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

Population Pharmacokinetics of Bepirovirsen in Healthy Participants and Participants with Chronic Hepatitis B Virus Infection: Results from Phase 1, 2a, and 2b Studies

Infectious Diseases and Therapy
Introduction Bepirovirsen is a novel antisense oligonucleotide in development for chronic hepatitis B virus (HBV) infection therapy. Understanding the impact that clinical characteristics may have on bepirovirsen exposure is important for determining ...
Amir S. Youssef, Mohamed Ismail, Kelong Han, Mindy Magee, Ahmed Nader   +4 more
doaj   +1 more source

Refinement of SDBC Business Process Models Using ISDL [PDF]

, 2006
Aiming at aligning business process modeling and software specification, the SDBC approach considers a multi-viewpoint modeling where static, dynamic, and data business process aspect models have to be mapped adequately to corresponding static, dynamic ...
Quartel, Dick, Shishkov, Boris
core   +1 more source

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

FEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino, Meijie Li, Cécile Fizames, Mattia Adamo, Laurence Lejay, Christian Dubos, Matthieu Platre, Antoine Martin   +7 more
wiley   +1 more source

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

CFD Simulation of an Industrial Dust Cyclone Separator: A Comparison with Empirical Models: The Influence of the Inlet Velocity and the Particle Size on Performance Factors in Situation of High Concentration of Particles

Journal of Engineering
The present work is dedicated to the study of multiphase turbulent and three-dimensional rotational flow in dust cyclones, a contribution to air pollution control.
Tchinda Vermande Paganel, Epee Fabrice Alban, Mezoue Adiang Cyrille, Claude Valery Ngayihi Abbe   +3 more
doaj   +1 more source

Unraveling the thermodynamic criteria for size-dependent spontaneous phase separation in soft porous crystals

Nature Communications, 2019
Soft porous crystals hold big promise as functional nanoporous materials due to their stimuli responsive flexibility. Here, molecular dynamics simulations reveal a new type of spatial disorder in mesoscale crystals that helps to understand the size ...
Sven M. J. Rogge, Michel Waroquier, Veronique Van Speybroeck   +2 more
doaj   +1 more source

Molecular Models for Vertebrate Limb Development [PDF]

, 1997
Randy L. Johnson, Clifford J. Tabin
openalex   +1 more source