Results 131 to 140 of about 4,440,560 (311)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Analysis of Enterprise Modeling Approaches for Modeling Business Strategy
A gap in the alignment of business and IT lies between strategy and IS, despite the advancements of enterprise modeling. The objective of our study is to compare various enterprise modeling approaches with respect to their ability to capture and ...
Giannoulis, Constantinos +5 more
core
Context Modeling: Task Model and Practice Model [PDF]
, 2007 Contextual Graphs are a context-based formalism used in various real-world applications. They allow a uniform representation of elements of reasoning and of contexts for describing different human tasks such as troubleshooting and interpretation. A contextual graph represents a task realization.
openaire +2 more sources
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
System Modeling in UML with Two-Hemisphere Model Driven Approach
System modeling in an object-oriented manner at the initial stage of software development can be considered as a comprehensive knowledge presentation, which enables the developer practice problem domain (instead of code) to reuse and to share ...
Ņikiforova, Oksana
core
CreatingWorlds with Words: Ontology-guided Conceptual Modeling for Institutional Domains
, 2017 Conceptual modeling is often viewed as an activity of representing a preexisting world that should be faithfully mirrored in an information system. This view is adequate for modeling physical domains but needs to be revised and extended for social and ...
Paul Johannesson +5 more
core +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Integrating Agile Modeling with Participative Enterprise Modeling
Agile Modeling (AM) provides a set of best practices of “light-weight” modeling to support the modeling process on a macro level within the agile development teams.
Stirna, Jānis, Kirikova, Mārīte
core
Extensible Modeling and Simulation Framework (XMSF) 2004 Project Summary Report [PDF]
, 2005 The Extensible Modeling and Simulation Framework (XMSF) is defined as a composable set of standards, profiles and recommended practices for web-based modeling and simulation.
Morse, Katherine +6 more
core +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source