Results 151 to 160 of about 4,440,560 (311)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Mesoscale meteorological modeling /
The 3rd edition of Mesoscale Meteorological Modeling is a fully revised resource for researchers and practitioners in the growing field of meteorological modeling at the mesoscale.
Pielke, Roger A.Sr.,author.
core
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Multidimensional Business Process Modeling
Business process models can be constructed in different contexts and from different perspectives. Each modeling context prescribes a particular subspace of the potential business process modeling space, which can be characterized by certain business ...
Peņicina, Ludmila +2 more
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The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Threat Modeling Designing for Security
, 2014 The only security book to be chosen as a Dr. Dobbs Jolt Award Finalist since Bruce Schneier's Secrets and Lies and Applied Cryptography!Adam Shostack is responsible for security development lifecycle threat modeling at Microsoft and is one of a handful ...
Shostack, Adam
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UML Modeling for Tea / Coffee Machine [PDF]
, 2012 Unified Modeling language (UML) is one of the important modeling languages used for the visual representation of the research problem. In the present paper, UML model is designed for the Tea / Coffee Machine which is used for the purpose of the public in
Mr. H. Venkateswara Reddy +2 more
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Modeling Devices With Nonlinear Voltage-Current Characteristics for Harmonic Studies
, 2004 This paper documents the modeling of harmonic sources with nonlinear voltage-current characteristics such as transformers, iron-core reactors, rotating machines, arc furnaces, energy efficient lightings, and some household electronic appliances.
IEEE Task Force on Harmonics Modeling and Simulation
core +1 more source