Results 141 to 150 of about 4,440,560 (311)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Improved Simulation of Antarctic Sea Ice by Parameterized Thickness of New Ice in a Coupled Climate Model

Geophysical Research Letters
Sea ice formation over open water exerts critical control on polar atmosphere‐ocean‐ice interactions, but is only crudely represented in sea ice models. In this study, a collection depth parameterization of new ice for flux polynya models is modified by ...
Yongjie Fang, Junchen Yao, Tongwen Wu, Fanghua Wu, Jianglong Li   +4 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Measurement and Simplified Modeling Method of the Non-composite Deflections of Steel Plate Girder Bridges

, 2005
Many of today's bridge construction projects are erected in stages to limit traffic interruptions or to minimize environmental impacts. Typically, one half of the bridge superstructure is constructed in the first stage and the other half constructed in ...
Paoinchantara, Nuttapone
core  

Analyzing the Modeling of Context with Ontologies [PDF]

, 2007
Ontologies are a widely accepted instrument for the modeling of context information. We consider the identification of the benefits and difficulties of ontology-based modeling to be an important next step to further improve the usability of ontologies in
Strang, Thomas, Krummenacher, Reto, Lausen, Holger, Kopecky, Jacek   +3 more
core  

Integrating a Tumor Size‐Overall Survival Model Into a Spatial Quantitative Systems Pharmacology Framework for Antibody‐Drug Conjugates in Non‐Small Cell Lung Cancer

CPT: Pharmacometrics & Systems Pharmacology
Antibody‐drug conjugate (ADC) development in solid tumors faces efficacy and safety challenges from heterogeneous target expression, limited tumor penetration, and off‐target payload exposure. We developed a spatial quantitative systems pharmacology (QSP)
Mehdi Nikfar, Richard Franzese, Herbert Struemper, Brett Howell, Murad Melhem   +4 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Gameplay Analytics and Player Modeling

, 2016
What are the limits in the current state of the art of gameplay analytics and player modeling? What are the big open challenge questions and low-hanging fruit? What is the relationship between analytics and player modeling? What are the opportunities for
Shaker, Noor
core   +1 more source

The Algorithmic Agent Perspective and Computational Neuropsychiatry: From Etiology to Advanced Therapy in Major Depressive Disorder

Entropy
Major Depressive Disorder (MDD) is a complex, heterogeneous condition affecting millions worldwide. Computational neuropsychiatry offers potential breakthroughs through the mechanistic modeling of this disorder.
Giulio Ruffini, Francesca Castaldo, Edmundo Lopez-Sola, Roser Sanchez-Todo, Jakub Vohryzek   +4 more
doaj   +1 more source