Results 161 to 170 of about 1,436,254 (268)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Joint modeling of longitudinal and time-to-event data for dynamic disease risk prediction using proteomics. [PDF]

Protein Sci
Lindén M, Ammunét T, Välikangas T, Elo LL, Suomi T.   +4 more
europepmc   +1 more source

Models of Models of Models of Models of Things

, 2017
openaire   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

State-transition and simulation-based modeling approaches for simulating the progression of dental caries: a scoping review. [PDF]

Front Oral Health
Teplitzky X, Gostilo D, Tsilingaridis G, Hamza B, Petrova L, Pulikkotil SJ.   +5 more
europepmc   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Beyond Integration: Unresolved Causal and Temporal Challenges in Multi-Domain QT Risk Modeling. [PDF]

Clin Cardiol
Mudasir M, Rafiq S.
europepmc   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Correction to: Population Pharmacokinetics of Bepirovirsen in Healthy Participants and Participants with Chronic Hepatitis B Virus Infection: Results from Phase 1, 2a, and 2b Studies

Infectious Diseases and Therapy
Amir S. Youssef, Mohamed Ismail, Kelong Han, Mindy Magee, Ahmed Nader   +4 more
doaj   +1 more source

Implicit 3D geological modeling method based on expert knowledge constraints: A case study from the Songshugang Mining District, Hengfeng County, Jiangxi Province, China. [PDF]

PLoS One
Jin W, Wu Z, Xu Z, Li H, Li B, Guo F, Zhang Z, Ma F, Li H, Lu P.   +9 more
europepmc   +1 more source