Results 51 to 60 of about 425,473 (267)
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
End‐to‐end visual grounding via region proposal networks and bilinear pooling
IET Computer Vision, 2019 Phrase‐based visual grounding aims to localise the object in the image referred by a textual query phrase. Most existing approaches adopt a two‐stage mechanism to address this problem: first, an off‐the‐shelf proposal generation model is adopted to ...
Chenchao Xiang +4 more
doaj +1 more source
Simulation Modeling of Reduced Glycosylation Effects on Potassium Channels of Mouse Cardiomyocytes
Frontiers in Physiology, 2022 Dilated cardiomyopathy (DCM) is the third most common cause of heart failure and the primary reason for heart transplantation; upward of 70% of DCM cases are considered idiopathic.
Haedong Kim +3 more
doaj +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Spatiotemporal prediction of air quality based on LSTM neural network
Alexandria Engineering Journal, 2021 Accurate monitoring of air quality is of great importance to our daily life. By predicting the air quality in advance, we can make timely warnings and defenses to minimize the threat to life.
Dewen Seng +4 more
doaj +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
International Journal of Distributed Sensor Networks, 2018 In recent years, semantic sensor networks are proposed, which apply ontologies to provide query capabilities and data access and allow users to express their needs at a conceptual level.
Huayou Si +4 more
doaj +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Unsupervised feature selection in binarization of real attributes for conceptual clustering [PDF]
ITM Web of ConferencesThis paper proposes an approach for processing noisy data to form homogeneous subgroups of objects based on Formal Concept Analysis (FCA). The approach involves binary encoding of heterogeneous features and unsupervised feature selection using the ...
Shkaberina Guzel +3 more
doaj +1 more source