Results 21 to 30 of about 2,072 (266)

Performance of a UHPFRC overlay in the rehabilitation of a typical asphalt pavement structure

Revista Ingeniería de Construcción, 2022
This study determine the mechanical performance of a 40 mm thick overlay using UHPFRC (Ultra High-Performance Concrete) as the outer surface for restoring a flexible pavement structure. A 30 m long test section was built, divided into two 15 m sections.
A. Meléndez, H. Vacca, Y. Alvarado
doaj   +1 more source

Permanent deformation models for a granular material used in road pavements [PDF]

Construction and Building Materials, 2006
[Abstract:] This paper analyses the permanent deformation performance of an unbound granular material that has been subjected to repeated triaxial loads. The study focuses on the evolution of the cumulative strain and includes a classification of the specimens according to the shakedown concept.
Pérez Pérez, Ignacio, Medina-Rodríguez, Luis, Romana García, Manuel   +2 more
openaire   +2 more sources

Evaluation of asphalt pavement layer bonding stress

Journal of Civil Engineering and Management, 2015
This study is to evaluate the bonding shear stress between asphalt pavement layered structures with emulsion and cutback asphalt as tack coat materials.
Jia-Chong Du
doaj   +1 more source

Laboratory Study and Investigation on Significance Level of Fatigue Phenomenon in Warm Mix Asphalt Modified with Nano-Silica [PDF]

Journal of Rehabilitation in Civil Engineering, 2020
The present research aims to conduct laboratory assessment on fatigue phenomenon in warm mix asphalt modified with nano-silica and including reclaimed asphalt pavement materials by the aid of review on self-healing behavior and measurement of validity of
Saber Kie Badroodi, Mahmood Reza Keymanesh, Gholamali Shafabakhsh   +2 more
doaj   +1 more source

Deterioration Modeling of Pavement Performance in Cold Regions Using Probabilistic Machine Learning Method

Infrastructures
Accurate and reliable modeling of pavement deterioration is critical for effective infrastructure management. This study proposes a probabilistic machine learning framework using Bayesian-optimized Natural Gradient Boosting (BO-NGBoost) to predict the ...
Zhen Liu, Xingyu Gu, Wenxiu Wu
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Effects of Landscape Design on Urban Microclimate and Thermal Comfort in Tropical Climate

Advances in Meteorology, 2018
A climate-responsive landscape design can create a more livable urban microclimate with adequate human comfortability. This paper aims to quantitatively investigate the effects of landscape design elements of pavement materials, greenery, and water ...
Wei Yang, Yaolin Lin, Chun-Qing Li
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source