Results 31 to 40 of about 2,072 (266)

Effects of Geometrical Parameters on Numerical Modeling of Pavement Granular Material [PDF]

Airfield and Highway Pavement 2013, 2013
Numerical modeling of the granular pavement materials is one of the modeling approaches which can be used to predict material response to specific loading conditions. This modeling is dependent on many factors and variables and includes assumptions for material behavior, loading conditions, geomechanical properties and geometrical parameters.
Behzad Ghadimi, Hossein Asadi, Hamid Nikraz, Colin Leek   +3 more
openaire   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Energy Consumption and Carbon Emissions in Asphalt Pavement Construction: A Lifecycle Assessment of a Modular Approach

Medžiagotyra
Asphalt mixtures are widely used composite materials in pavement engineering, and their evaluation increasingly requires consideration of both functional performance and environmental sustainability.
Wei WEI, Yongjie DING, Haoming WANG, Jiaojiao WANG, Heng YAN   +4 more
doaj   +1 more source

Effect of Temperature Variation on Rigid Pavement Dowel [PDF]

Journal of Rehabilitation in Civil Engineering
Given its location along the equator, Indonesia has a tropical climate with two rainy and dry seasons. The significant variations in temperature that each season brings about are important factors when building civil engineering projects, including rigid
Anno Mahfuda, Suprapto Siswosukarto, Muh Karimi   +2 more
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

A FEM Modeling of the Concrete Pavement Made of the Recycling Material

MATEC Web of Conferences, 2016
Paper is a brief review of the research focused on formulation an numerical model for the concrete pavement which is made by the recycling material. For numerical modeling the finite element model (FEM) and the 3D finite element model were applied. The software EverFE 2.25, was used.
Šešlija Miloš, Radović Nebojša, Togo Issa   +2 more
openaire   +2 more sources

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Deep learning-based modeling of sulfur-extended asphalt (SEA) properties: a novel computational framework [PDF]

PeerJ Computer Science
This research presents a deep learning method for modeling the properties of sulfur-extended asphalt (SEA), a material that has the potential to enhance pavement durability and sustainability.
Muhammad Ali Martuza, Sayeed Rushd, Md Arifuzzaman   +2 more
doaj   +2 more sources

Deterioration Models for Bridge Pavement Materials for a Life Cycle Cost Analysis

Sustainability, 2022
As the Framework Act on Sustainable Infrastructure Management has recently been enacted in Korea, it has become mandatory to establish a medium-and long-term plan for managing social infrastructure and evaluating the feasibility of maintenance projects.
Daeseok Han, Jin-Hyuk Lee, Ki-Tae Park
openaire   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source