Results 51 to 60 of about 603,423 (297)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Teaching complexity in biology through agent-based simulations: the relationship between students’ knowledge of complex systems and metamodeling knowledge

Frontiers in Education, 2023
Real-world complex systems research seeks to understand how systems in the world can follow the same rules of complexity. Scientists have found similarities in processes—such as self-organization, micro-to macro-level emergence, and feedback loops—in ...
Katherine M. Miller, Susan A. Yoon
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Inadequacy of SIR model to reproduce key properties of real-world spreading cascades: experiments on a large-scale P2P system [PDF]

Social Network Analysis and Mining, 2013
Understanding the spread of information on complex networks is a key issue from a theoretical and applied perspective. Despite the effort in developing theoretical models for this phenomenon, gauging them with large-scale real-world data remains an important challenge due to the scarcity of open, extensive and detailed data.
Bernardes, Daniel, Latapy, Matthieu, Tarissan, Fabien   +2 more
openaire   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Epidemic processes in complex networks [PDF]

, 2015
In recent years the research community has accumulated overwhelming evidence for the emergence of complex and heterogeneous connectivity patterns in a wide range of biological and sociotechnical systems. The complex properties of real-world networks have
Adar, E., Alessandro Vespignani, Anderson, R. M., Andersson, H., Bailey, N. T. J., Baroyan, O. V., Barrat, A., ben-Avraham, D., Bernoulli, D., Binder, K., Boguñá, M., Brauer, F., Caldarelli, G., Claudio Castellano, Cohen, R., Cox, D. R., Diekmann, O., Diekmann, O., Domingos, P., Dorogovtsev, S. N., Dorogovtsev, S. N., Easley, D., Erdős, P., Ganesh, A., Gantmacher, F. R., Gourdin, E., Gruhl, D., Hammersley, J. M., Hanski, I., Henkel, M., Hethcote, H., Hui, P., Jackson, M., Keeling, M., Kempe, D., Kesten, H., Kooij, R., Lerman, K., Leskovec, J., Levins, R., Maki, D. P., Marro, J., Newman, M., Omic, J., Pastor-Satorras, R., Peng, S., Piet Van Mieghem, Rogers, E. M., Romualdo Pastor-Satorras, Ross, S. M., Sahneh, F. D., Schumm, P., Stanley, H. E., Stauffer, D., Tijms, H., van Kampen, N. G., Van Mieghem, P., Van Mieghem, P., Van Mieghem, P., Ver Steeg, G., Wang, Y., Wasserman, S., Webb, J. N., Weng, L., Wilf, H. S., Yeomans, J. M.   +65 more
core   +3 more sources

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Marginal productivity index policies for scheduling a multiclass delay-/loss-sensitive queue [PDF]

, 2005
We address the problem of scheduling a multiclass M/M/1 queue with a finite dedicated buffer for each class. Some classes are delay-sensitive, modeling real-time traffic (e.g.
Niño Mora, José
core  

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source