Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay +2 more
wiley +1 more source
Joint Modeling and Analysis Using XMSF Web Services [PDF]
Proceedings of the 2004 Winter Simulation Conference, R .G. Ingalls, M. D. Rossetti, J. S. Smith, and B. A. Peters, eds.This paper describes the creation of a new analytical modeling capability by bringing together the Naval Simulation System (NSS) for ...
Buss, Arnold H., Ruck, John
core +2 more sources
Pathways and pitfalls: a qualitative study of student experiences in biomedical science education
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell +8 more
wiley +1 more source
MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss +7 more
wiley +1 more source
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti +5 more
wiley +1 more source
GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain +11 more
wiley +1 more source
چالشهای استقرار حسابهای استانی سلامت: مطالعه موردی استان کرمان
مقدمه: شرط دستیابی به اهداف نظام سلامت، بهرهمندی عادلانه افراد جامعه از خدمات سلامت کارا و اثربخش میباشد. عادلانه بودن خدمات سلامت و مشارکت عادلانه مردم بستگی زیادی به نظام تامین مالی دارد که در این راستا، نظام اطلاعات مالی برای تصمیمگیری در نظام ...
MohammadHossein Mehrolhassani +2 more
doaj
Comparative assessment of crystallographic and cryo‐EM models in the Protein Data Bank
Raw data obtained by X‐ray crystallography or cryo‐EM result in experimental maps, ultimately fitted by atomic models. Although the physical principles are different, the final results can be viewed, compared, and evaluated in the same way. With cryogenic electron microscopy (cryo‐EM) on track to surpass X‐ray crystallography as the preferred method ...
Alexander Wlodawer +7 more
wiley +1 more source
Three Speed Controllers of Direct Torque Control for a Doubly Fed Induction Motor Drive–A Comparison
Mohammed El Mahfoud +4 more
doaj +1 more source
Assessing Performance of Kerman Province`s Hospitals Using Pabon Lasso Diagram between 2008 and 2010
Background: A method of performance assessment is required to improve Productivity and reduce hospital costs . Pabon Lasso diagram is known as a tool for performance assessment.
M Mehrolhasani +2 more
doaj

