Results 81 to 90 of about 257,496 (267)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Using ontology and semantic web services to support modeling in systems biology
, 2009 This thesis addresses the problem of collaboration among experimental biologists and modelers in the study of systems biology by using ontology and Semantic Web Services techniques.
Sun, Z.
core
Semi-automatic distribution pattern modeling of web service compositions using semantics [PDF]
, 2006 Enterprise systems are frequently built by combining a number of discrete Web services together, a process termed composition. There are a number of architectural configurations or distribution patterns, which express how a composed system is to be ...
Ronan Barrett +3 more
core +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Trade in Intermediate Producer Services under Imperfect Competition [PDF]
In this paper a stylized CGE model is constructed to study the impact of liberalization of barriers for foreign providers of intermediate producer services under imperfect competition on the welfare, the downstream industry output, the prices of the ...
Aidan Islyami
core
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Study of Hospital Waste Management in Hospitals of Kerman University of Medical Sciences during the Years 2012- 2013 [PDF]
پژوهشهای سلامتمحور, 2015 Introduction: Hospital wastes have high sensitivity due to their hazardous, toxic, and pathogenic agent's contents therefore, proper management of them plays an important role in the control of environmental pollution and occurrence of hospital ...
Manoochehr Khazaee +6 more
doaj
BMC Public Health, 2019 Background Description of the epidemiology of influenza is needed to inform influenza vaccination policy. Here we examined influenza virus circulation in countries in the Asia-Pacific region and compared the timing of seasonal epidemics with the timing ...
Clotilde El Guerche-Séblain +4 more
doaj +1 more source
A design framework for identifying optimum services using choreography and model transformation
, 2012 Service Oriented Architecture (SOA) has become an effective approach for implementing loosely-coupled and flexible systems based on a set of services.
Alahmari, Saad
core