Results 41 to 50 of about 199,947 (264)

service-oriented approach for interactive computing systems

Publicaciones en Ciencias y Tecnología, 2011
The introduction of new technologies leads to a more and more complex interactive systems design. In order to describe the future interactive system, the human computer interaction domain uses specific models, design processes and tools in order to ...

doaj  

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Time trend and geographical distribution of major depressive disorder in Iran, 1990 to 2021: results from the Global Burden of Disease Study

BMJ Open
Objective Major depressive disorder (MDD) is a disabling disease and is recognised as a serious, public health concern. In this study, we aimed to determine the burden and trends of MDD in Iran.Design and participants Secondary data from the Global ...
Moslem Taheri Soodejani, Fateme Shakeri Shamsi   +1 more
doaj   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Ecosystems and Their Digital Models as Factors of Algocognitive Culture and Transition to New Technological Order

Social Sciences, 2023
In the paradigm of dissipative structures based on theories of economic and regional development, business networks, and the theory of algocognitive culture, the authors studied the processes of the formation of ecosystem formats for business development
Vasilii V. Kuimov, Konstantin V. Simonov, Eva V. Shcherbenko, Liudmila V. Iushkova   +3 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Estimated public health impact of concurrent mask mandate and vaccinate-or-test requirement in Illinois, October to December 2021

BMC Public Health
Background Facing a surge of COVID-19 cases in late August 2021, the U.S. state of Illinois re-enacted its COVID-19 mask mandate for the general public and issued a requirement for workers in certain professions to be vaccinated against COVID-19 or ...
François M. Castonguay, Arti Barnes, Seonghye Jeon, Jane Fornoff, Bishwa B. Adhikari, Leah S. Fischer, Bradford Greening, Adebola O. Hassan, Emily B. Kahn, Gloria J. Kang, Judy Kauerauf, Sarah Patrick, Sameer Vohra, Martin I. Meltzer   +13 more
doaj   +1 more source

Effective Factors on Postgraduate Students Research experience in Kerman University of Medical Sciences [PDF]

Pizhūhish dar Āmūzish-i ̒ulūm-i Pizishkī, 2016
Background: Today majority of researches in universities of medical sciences belong to post graduates students, thus qualitative assessment of current situation dominated on research in post graduates courses as well as evaluation of research experiences 
S Noori Hekmat, M Rezaei, R Dehnavieh
doaj  

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source