Results 41 to 50 of about 257,496 (267)

The public health impact of COVID-19 variants of concern on the effectiveness of contact tracing in Vermont, United States

open access: yesScientific Reports
Case investigation and contact tracing (CICT) are public health measures that aim to break the chain of pathogen transmission. Changes in viral characteristics of COVID-19 variants have likely affected the effectiveness of CICT programs. We estimated and
François M. Castonguay   +11 more
doaj   +1 more source

Review of the Statistical methods used in original articles Published in Iranian Journal of Public Health: 2015-2019

open access: yesIranian Journal of Public Health, 2021
Background: Nowadays, statistical methods are used frequently in research articles. This review study aimed to determine the statistical methods used in original articles published in Iranian journal of public health (IJPH). Methods: Original articles
Sajjad Bahariniya, Farzan Madadizadeh
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

open access: yesFEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas   +3 more
wiley   +1 more source

service-oriented approach for interactive computing systems

open access: yesPublicaciones en Ciencias y Tecnología, 2011
The introduction of new technologies leads to a more and more complex interactive systems design. In order to describe the future interactive system, the human computer interaction domain uses specific models, design processes and tools in order to ...

doaj  

Joint Modeling and Analysis Using XMSF Web Services [PDF]

open access: yes, 2004
Proceedings of the 2004 Winter Simulation Conference, R .G. Ingalls, M. D. Rossetti, J. S. Smith, and B. A. Peters, eds.This paper describes the creation of a new analytical modeling capability by bringing together the Naval Simulation System (NSS) for
Buss, Arnold H., Ruck, John
core  

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Time trend and geographical distribution of major depressive disorder in Iran, 1990 to 2021: results from the Global Burden of Disease Study

open access: yesBMJ Open
Objective Major depressive disorder (MDD) is a disabling disease and is recognised as a serious, public health concern. In this study, we aimed to determine the burden and trends of MDD in Iran.Design and participants Secondary data from the Global ...
Moslem Taheri Soodejani   +1 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, Volume 20, Issue 6, Page 1626-1642, June 2026.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Ecosystems and Their Digital Models as Factors of Algocognitive Culture and Transition to New Technological Order

open access: yesSocial Sciences, 2023
In the paradigm of dissipative structures based on theories of economic and regional development, business networks, and the theory of algocognitive culture, the authors studied the processes of the formation of ecosystem formats for business development
Vasilii V. Kuimov   +3 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, Volume 20, Issue 6, Page 1453-1472, June 2026.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

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