Results 161 to 170 of about 28,765,428 (344)

Modeling and Analysis of Signal Transduction Networks [PDF]

, 2016
Biological pathways, such as signaling networks, are a key component of biological systems of each living cell. In fact, malfunctions of signaling pathways are linked to a number of diseases, and components of signaling pathways are used as potential ...

core   +1 more source

Software and Hardware Tools for Modeling Digital Twins

Кібернетика та комп'ютерні технології
Introduction. A digital twin dynamically reflects and simulates the behavior of its physical counterpart. To predict the behavior of a digital twin under certain conditions, it is necessary to create a large database and develop a software model ...
Oleksandr Timashov, Kateryna Sosnenko, Tamara Samoliuk   +2 more
doaj   +1 more source

Magnetosphere-Ionosphere-Thermosphere Coupling Study at Jupiter Based on Juno's First 30 Orbits and Modeling Tools. [PDF]

J Geophys Res Space Phys, 2022
Al Saati S, Clément N, Louis C, Blanc M, Wang Y, André N, Lamy L, Bonfond B, Collet B, Allegrini F, Bolton S, Clark G, Connerney JEP, Gérard JC, Gladstone GR, Kotsiaros S, Kurth WS, Mauk B.   +17 more
europepmc   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

A Preliminary Study of Magnetosphere-Ionosphere-Thermosphere Coupling at Jupiter: Juno Multi-Instrument Measurements and Modeling Tools. [PDF]

J Geophys Res Space Phys, 2021
Wang Y, Blanc M, Louis C, Wang C, André N, Adriani A, Allegrini F, Blelly PL, Bolton S, Bonfond B, Clark G, Dinelli BM, Gérard JC, Gladstone R, Grodent D, Kotsiaros S, Kurth W, Lamy L, Louarn P, Marchaudon A, Mauk B, Mura A, Tao C.   +22 more
europepmc   +1 more source

Business process modeling tools

, 2009
Paper summarizes the importance of process management and process modeling for the organization. The primary goal of this paper is to give an overview of available software tools for modeling business processes.
Mareček, Jaromír
core  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Opening a debate on open-source modeling tools: Pouring fuel on fire versus extinguishing the flare of a healthy debate. [PDF]

CPT Pharmacometrics Syst Pharmacol, 2021
Rostami-Hodjegan A, Bois FY.
europepmc   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source