Results 51 to 60 of about 341,194 (266)
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Are you using the right tools in computational electromagnetics?
Engineering Reports, 2019 Have you ever wondered why we use certain computational electromagnetics methods and how we decide on the choice of tools for modeling problems in electromagnetics?
Krishnaswamy Sankaran
doaj +1 more source
Visual Modeling Tools for Problem-Based Learning for Teaching High School Programming
Современные информационные технологии и IT-образование, 2020 This article is dedicated to the developing of methodology for teaching high school students computer science disciplines like algorithms and programming, using a problem-based learning with visual modeling tools.
Sergei Kostousov, Irina Simonova
doaj +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Evaluating Image-Based Interactive 3D Modeling Tools
IEEE AccessStructure from Motion (SfM) is a computer vision technique used to reconstruct three-dimensional (3D) structures from a series of two-dimensional (2D) images or video frames.
Arslan Siddique +3 more
doaj +1 more source
Supplemental data acquisition tools for modeling environmental systems
Revista de Matemática: Teoría y Aplicaciones, 2009 The goal of our on-going research is to develop effective and reliable tools for modeling the environmental systems of the Gulf of Mexico. For example, our on-going research into methodologies for the prediction of water levels in the shallow waters of ...
Carl W. Steidley +2 more
doaj +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
Molecules, 2020 Proteins are among the most important molecules on Earth. Their structure and aggregation behavior are key to their functionality in living organisms and in protein-rich products.
Faiza Rasheed +3 more
doaj +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source