Results 111 to 120 of about 3,680,706 (288)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Conceptual modelling: framework, principles, and future research [PDF]

, 2007
The conceptual modelling task in a simulation project is very important and yet is still generally regarded as more of an art than a science. The meaning and nature of conceptual modelling are discussed and a framework set out.
Brooks, R J
core  

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Temporal patterns of instrumentation failures in atmospheric boundary layer observational systems [PDF]

E3S Web of Conferences
his study examines characteristic patterns associated with equipment failures in time series data from urban environmental monitoring systems. While prolonged data gaps represent the most apparent failure indicator, equipment malfunctions manifest ...
Karepova Eugeniya, Shan’ko Yury, Tokarev Alexei, Petrakova Viktoriya   +3 more
doaj   +1 more source

Modelling and simulation framework for reactive transport of organic contaminants in bed-sediments using a pure java object - oriented paradigm [PDF]

, 2006
Numerical modelling and simulation of organic contaminant reactive transport in the environment is being increasingly relied upon for a wide range of tasks associated with risk-based decision-making, such as prediction of contaminant profiles ...
Allan, I., Go, J., Roberts, G., Stegemann, J.   +3 more
core  

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

The use of technology of separating horizontal wells into sections by packers in conjunction with a new geological structure concept of deposits 302-302 of the Romashkino Field

Georesursy, 2018
The work considers deposits 302-303 of the Bashkirian and Serpukhovian stages. The Kuakbashsky deposits 302-303 are confined to the carbonate layer of the Bashkirian and Serpukhovian sediments of the Middle and Lower Carboniferous, with various types of ...
Z.A. Loscheva, I.V. Nigmadzyanova, A.A. Nazarov, M.K. Bukatov   +3 more
doaj   +1 more source

Modelling Citation Networks

, 2014
The distribution of the number of academic publications as a function of citation count for a given year is remarkably similar from year to year. We measure this similarity as a width of the distribution and find it to be approximately constant from year
Anthony, H., Evans, T. S., Goldberg, S. R.   +2 more
core   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Investigation of Ti-Pt-V high temperature shape memory alloys towards aerospace applications: A cluster expansion screening [PDF]

MATEC Web of Conferences
TiPt has a higher martensitic transformation above 1200 K, which makes it a good candidate for HTMSAs. However, TiPt exhibits C′ = -32GPa. A new class of Ti-Pt-V systems was predicted using cluster expansion.
Mashamaite Mordecai, Ngoepe Phuti, Chauke Hasani   +2 more
doaj   +1 more source