Results 121 to 130 of about 1,160,554 (311)

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

Molecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

Encoding Multi-Resolution Brain Networks Using Unsupervised Deep Learning

, 2017
The main goal of this study is to extract a set of brain networks in multiple time-resolutions to analyze the connectivity patterns among the anatomic regions for a given cognitive task.
Alchihabi, Abdullah, Antsaklis, Panos, Gupta, Vijay, Rahnama, Arash, Vural, Fatos T. Yarman   +4 more
core   +1 more source

Understanding and measuring mechanical signals in the tumor stroma

FEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz, Chiara Cimmino, Maurizio Ventre, Alessandra Cambi   +3 more
wiley   +1 more source

Rib fractures in the elderly: physiology trumps anatomy

Trauma Surgery & Acute Care Open, 2019
Introduction Rib fractures in elderly patients are associated with increased morbidity and mortality. Predicting which patients are at risk for complications is an area of debate.
Nathan Schmoekel, Jon Berguson, Jerry Stassinopoulos, Efstathios Karamanos, Joe Patton, Jeffrey L Johnson   +5 more
doaj   +1 more source

Individual differences in human path integration abilities correlate with gray matter volume in retrosplenial cortex, hippocampus, and medial prefrontal cortex [PDF]

, 2017
Humans differ in their individual navigational abilities. These individual differences may exist in part because successful navigation relies on several disparate abilities, which rely on different brain structures.
Aselcioglu, Irem, Chrastil, Elizabeth R., Hasselmo, Michael E., Sherrill, Katherine R., Stern, Chantal E.   +4 more
core   +1 more source

Positive feedback loop between MAPK and aquaporin 7 regulates autophagy and apoptosis induced by palmitate in RIN‐m5f cells

FEBS Open Bio, EarlyView.
T2DM is characterized by peripheral blood insulin resistance and progressive pancreatic β‐cell dysfunction. Here, we showed that AQP7, the only aquaglyceroporin protein, regulates autophagy and apoptosis in pancreatic β‐cells. We propose the existence of a positive feedback loop between MAPK signaling and AQP7 that regulates autophagy and apoptosis in ...
Maoqi Wang, Jiang Tan, Xueting He, Yuqin Chen, Guoping Qiu, Mei Yang   +5 more
wiley   +1 more source

The use of human tissue surrogates in anatomical modeling for gunshot wounds simulations: an overview about “how to do” experimental terminal ballistics

Frontiers in Bioengineering and Biotechnology
Human tissue simulating materials are currently used in scientific research mainly because they help to avoid possible ethical issues, unlike what happens with studies involving live animals and/or human cadavers.
Lucas Meciano Pereira dos Santos, Marcelo Rodrigues da Cunha, Carlos Henrique Bertoni Reis, Daniela Vieira Buchaim, Daniela Vieira Buchaim, Ana Paula Bernardes da Rosa, Leandro Moreira Tempest, José Augusto Parola da Cruz, Rogério Leone Buchaim, Rogério Leone Buchaim, João Paulo Mardegan Issa, João Paulo Mardegan Issa   +11 more
doaj   +1 more source

Anatomical Modelling of the Pregnant Radiotherapy Patient [PDF]

, 2015
This study aimed to take existing anatomical models of pregnant women, currently used for radiation protection and nuclear medicine dose calculations, and adapt them for use in the calculation of fetal dose from external beam radiotherapy (EBRT). The models investigated were ‘KATJA’, which was provided as an MCNPX geometry file, and ‘RPI-P6’, which was
Kairn, Tanya, Crowe, Scott, Mitchell, J., Schlect, David, Trapp, Jamie   +4 more
openaire   +3 more sources

A non‐fluorescent immunohistochemistry method for measuring autophagy flux using MAP1LC3/LC3 and SQSTM1 as core markers

FEBS Open Bio, EarlyView.
We introduce an immunohistochemistry method to measure autophagy flux, highlighting the active degradation and recycling of cellular waste. This cost‐effective approach uses tissue samples to track key markers like LC3 and SQSTM1, revealing how cells maintain health or respond to diseases such as cancer. It bridges the gap between research and clinical
Shahla Shojaei, Amir Barzegar Behrooz, Marco Cordani, Mahmoud Aghaei, Negar Azarpira, Daniel J. Klionsky, Saeid Ghavami   +6 more
wiley   +1 more source