Results 231 to 240 of about 9,617,821 (263)

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

6-gingerol modulates lipid metabolism, insulin resistance, and inflammation in NAFLD: evidence from a preclinical meta-analysis. [PDF]

Front Nutr
Jin D, Jin S, Zhou T, Li H, Li G, Qin C, Ying W, Sheng G, Gao P.   +8 more
europepmc   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Integration of microphysiological systems with computational and digital twin modeling for pharmaceutical development: a systematic review. [PDF]

J Pharm Pharm Sci
Soheili M, Gilzad Kohan B, Rastegar L, Moradi Y, Gilzad Kohan H.   +4 more
europepmc   +1 more source

Organ Chips and Translational Research: Identifying and Examining New Ethical Issues. [PDF]

Ethics Hum Res
Jeske M.
europepmc   +1 more source

Improving physiological monitoring and reporting standards in preclinical stroke research. [PDF]

J Cereb Blood Flow Metab
Premilovac D, Coombe HE, Trotman-Lucas M, Beard DJ, Stuckey SM, Morris GP, Hood RJ.   +6 more
europepmc   +1 more source

Physical exercise as a therapeutic strategy in animal models of Alzheimer's disease: Molecular, behavioral, and histopathological evidence. [PDF]

Biochem Biophys Rep
Behrouzfar H, Gholami M, Hassani S, Maghsoudi AS, Bekheir SA.   +4 more
europepmc   +1 more source

Etiology-oriented rodent models of erectile dysfunction: a narrative review of categorization, modeling strategies, and translational applications. [PDF]

Transl Androl Urol
Yin F, Chen H, Tu H, Zhong H, Mo Y, Xie T, Lai Z, Zou J, Xiao R.   +8 more
europepmc   +1 more source