Results 261 to 270 of about 3,154,795 (303)
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2018
Animal assays represent an important stage between in vitro studies and human clinical applications. These models are crucial for biomedical research and regenerative medicine studies, as these offer precious information for systematically assessing the efficacy and risks of recently created biomaterials, medical devices, drugs, and therapeutic ...
da Silva Morais, Alain +2 more
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Animal assays represent an important stage between in vitro studies and human clinical applications. These models are crucial for biomedical research and regenerative medicine studies, as these offer precious information for systematically assessing the efficacy and risks of recently created biomaterials, medical devices, drugs, and therapeutic ...
da Silva Morais, Alain +2 more
openaire +3 more sources
2003
Cancer is a prevalent and poorly understood disease in human populations. It is generally viewed as a complex, genetic, multistep process involving a series of independent events, each of which creates an incremental phenotypic aberration. For example, the capabilities for extended proliferation, invasion of adjacent tissue, and distant metastasis ...
C T, Guy, G, Cardoso
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Cancer is a prevalent and poorly understood disease in human populations. It is generally viewed as a complex, genetic, multistep process involving a series of independent events, each of which creates an incremental phenotypic aberration. For example, the capabilities for extended proliferation, invasion of adjacent tissue, and distant metastasis ...
C T, Guy, G, Cardoso
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Hearing Research, 2016
Presented is a thematic review of animal tinnitus models from a functional perspective. Chronic tinnitus is a persistent subjective sound sensation, emergent typically after hearing loss. Although the sensation is experientially simple, it appears to have central a nervous system substrate of unexpected complexity that includes areas outside of those ...
Thomas J, Brozoski, Carol A, Bauer
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Presented is a thematic review of animal tinnitus models from a functional perspective. Chronic tinnitus is a persistent subjective sound sensation, emergent typically after hearing loss. Although the sensation is experientially simple, it appears to have central a nervous system substrate of unexpected complexity that includes areas outside of those ...
Thomas J, Brozoski, Carol A, Bauer
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Psychosomatics, 1992
This study describes an animal model for delirium comparing rats treated with either saline or atropine. The model was defined by recordings of cortical EEGs, maze performance, and behavioral observations. EEG slowing and increased amplitude, difficulty with attention and memory, sleep-wake cycle reversal, and changes in behavior (lack of focused ...
P T, Trzepacz, M, Leavitt, K, Ciongoli
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This study describes an animal model for delirium comparing rats treated with either saline or atropine. The model was defined by recordings of cortical EEGs, maze performance, and behavioral observations. EEG slowing and increased amplitude, difficulty with attention and memory, sleep-wake cycle reversal, and changes in behavior (lack of focused ...
P T, Trzepacz, M, Leavitt, K, Ciongoli
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Critical Care Clinics, 2009
In this review, we start with a general discussion of relevant factors that can determine the validity of a sepsis animal model. We briefly review some of the currently used animal models of sepsis (small animal models and large animal models). We discuss the clinical relevance of animal models in sepsis research today and address potential reasons for
Sergio L, Zanotti-Cavazzoni +1 more
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In this review, we start with a general discussion of relevant factors that can determine the validity of a sepsis animal model. We briefly review some of the currently used animal models of sepsis (small animal models and large animal models). We discuss the clinical relevance of animal models in sepsis research today and address potential reasons for
Sergio L, Zanotti-Cavazzoni +1 more
openaire +2 more sources
Disability and Rehabilitation, 2008
The term tendinopathy describes non-ruptured tendon injuries. While several important studies have evaluated the aetiology, pathogenesis, and treatment of this common condition, further study is needed. Several animal models, which allow for full tissue evaluation on different organizational levels and stages of disease, have been used to investigate ...
Spencer P, Lake +2 more
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The term tendinopathy describes non-ruptured tendon injuries. While several important studies have evaluated the aetiology, pathogenesis, and treatment of this common condition, further study is needed. Several animal models, which allow for full tissue evaluation on different organizational levels and stages of disease, have been used to investigate ...
Spencer P, Lake +2 more
openaire +2 more sources
Trends in Cardiovascular Medicine, 1994
Percutaneous transluminal coronary angioplasty is a widely used technique for recanalizing arteries that are occluded by atherosclerotic plaque, but its usefulness is limited by the occurrence ofrestenosis in a high proportion of patients. The development of new therapies for this currently intractable problem will be facilitated by the use of animal ...
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Percutaneous transluminal coronary angioplasty is a widely used technique for recanalizing arteries that are occluded by atherosclerotic plaque, but its usefulness is limited by the occurrence ofrestenosis in a high proportion of patients. The development of new therapies for this currently intractable problem will be facilitated by the use of animal ...
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Behaviour Research and Therapy, 2004
An animal model of sexual fetishism was developed with male Japanese quail based on persistence of conditioned sexual responding during extinction to an inanimate object made of terrycloth (Experiments 1 and 3). This persistent responding occurred only in subjects that came to copulate with the terrycloth object, suggesting that the copulatory behavior
Falih, Köksal +6 more
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An animal model of sexual fetishism was developed with male Japanese quail based on persistence of conditioned sexual responding during extinction to an inanimate object made of terrycloth (Experiments 1 and 3). This persistent responding occurred only in subjects that came to copulate with the terrycloth object, suggesting that the copulatory behavior
Falih, Köksal +6 more
openaire +2 more sources
Modeling Depression in Animal Models
2011Animal models and preclinical tests have played large roles in the development of antidepressant drugs and are likely to continue to play important roles. In the present communication, the main animal models of depression have been described and reviewed.
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