Results 21 to 30 of about 9,617,821 (263)

Bridging the Loneliness Gap: Depression, Connectivity, and Isolation in Pediatric Oncology Patients and Their Peers

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Loneliness is associated with adverse physical and mental health outcomes and remains understudied in children and adolescents undergoing cancer therapy. Pediatric oncology patients may be at increased risk due to medical isolation and disruption of social networks.
Charlotte N. Stahlfeld, Scott H. Maurer, Michelle D. Watkinson, John Nury, Elise Barberis, Molly C. Mack   +5 more
wiley   +1 more source

Neuroprotective effects of hypoactive Akkermansia muciniphila in MPTP-induced mouse models of Parkinson’s disease

Microbiology Spectrum
Parkinson’s disease (PD) has been associated with the microbiota-gut-brain axis, and probiotics have been shown to alleviate PD symptoms via various mechanisms.
Jiahui Xi, Chengcheng Tang, Xian Xiao, Min Chen, Qingjian Zou, Xiaoqing Zhou   +5 more
doaj   +1 more source

Therapeutic potential of human umbilical cord mesenchymal stem cells on aortic atherosclerotic plaque in a high-fat diet rabbit model

Stem Cell Research & Therapy, 2021
Background Atherosclerosis (AS) is a complex disease caused in part by dyslipidemia and chronic inflammation. AS is associated with serious cardiovascular disease and remains the leading cause of mortality worldwide.
Yanhong Li, Guiying Shi, Yunlin Han, Haiquan Shang, Huiwu Li, Wei Liang, Wenjie Zhao, Lin Bai, Chuan Qin   +8 more
doaj   +1 more source

Pediatric Idiopathic Multicentric Castleman Disease Is Often Severe But Responsive to Siltuximab

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Idiopathic multicentric Castleman disease (iMCD) is a potentially fatal immunologic disorder marked by widespread lymphadenopathy and inflammation. Siltuximab, an interleukin‐6 (IL‐6) inhibitor, is the only FDA‐approved treatment for adult patients with iMCD.
Bridget Austin, Sheila K. Pierson, Kelley C. Dacus, Mateo Sarmiento Bustamante, Saishravan Shyamsundar, Larissa Borys, Kayla McHugh, Abiola Irvine, Yoojin Jo, Adam Bagg, Mary Jo Lechowicz, Daisy Alapat, Amy Chadburn, Megan S. Lim, Gordan Srkalovic, Frits van Rhee, David C. Fajgenbaum, Joshua D. Brandstadter   +17 more
wiley   +1 more source

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

A novel efficient strategy to generate liver sinusoidal endothelial cells from human pluripotent stem cells

Scientific Reports
Liver sinusoidal endothelial cells (LSECs) are highly specialized endothelial cells (ECs) that play an important role in liver development and regeneration. Additionally, it is involved in various pathological processes, including steatosis, inflammation,
Shang-Ping Tian, Jian-Yun Ge, Yu-Mu Song, Xiao-Qing Yu, Wen-Hao Chen, Yu-Ying Chen, Di Ye, Yun-Wen Zheng   +7 more
doaj   +1 more source

Formononetin promotes porcine oocytes maturation and improves embryonic development by reducing oxidative stress

Frontiers in Cell and Developmental Biology
Increasing evidence has demonstrated that oxidative stress impairs oocyte maturation and embryonic development. Conventionally, antioxidants have been applied in vitro systems to improve oocyte maturation and blastocyst rates.
Na Wang, Han Yang, Yelei Chen, Hekun Wang, Chaorui Wang, Jianglin Fan, Yajie Chen, Yinghua Li, Maobi Zhu   +8 more
doaj   +1 more source

Animal models for COVID-19 [PDF]

, 2020
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the aetiological agent of coronavirus disease 2019 (COVID-19), an emerging respiratory infection caused by the introduction of a novel coronavirus into humans late in 2019 (first detected in
García-Sastre, Adolfo, Krause, Philip R., Herfst, Sander, Knezevic, Ivana, Rockx, Barry, Chan, Jasper F.W., Henao-Restrepo, Ana Maria, Guilfoyle, Kate, Salguero, Francisco J., Liu, Wen-Chun, Gsell, Pierre S., Crozier, Ian, Funnell, Simon G.P., Brasel, Trevor, de Wit, Emmie, Hamilton, Geraldine A., Richt, Jürgen A., Albrecht, Randy A., Klimstra, William, Krause, Phillip R., Serra Gironella, Joan, Dallmeier, Kai, Stittelaar, Koert J., Frieman, Matthew B., Le Grand, Roger, de Waal, Leon, Maisonnasse, Pauline, Lewis, Mark G., Vergara-Alert, Júlia, Richt, Juergen A., Thibaut, Hendrik Jan, Riveros-Balta, A. Ximena, Haagmans, Bart L., Beer, Martin, Klimstra, William B., Dohm, Erik, Duprex, W.P., Schotsaert, Michael, Dowling, William E., McElroy, Anita K., Finch, Courtney L., Kuhn, Jens H., Roy, Chad J., Chan, Jasper F. W., Falzarano, Darryl, Rasmussen, Angela L., Funnell, Simon G. P., Reed, Douglas S., Carroll, Miles W., Qin, Chuan, Rogers, Thomas, Neyts, Johan, Rogers, Thomas F., Rocha-Pereira, Joana, Graham, Barney S., Hartman, Amy L., Segalés, Joaquim, Munster, Vincent, Rodríguez, Estefania, Oreshkova, Nadia, Duprex, W. Paul, Gralinski, Lisa, Muñoz-Fontela, César, Oreshkova, N.D., Perlman, Stanley, Barouch, Dan H., Kaptein, Suzanne J. F., Stittelaar, Koert, Gsell, Pierre-S., Andersen, Hanne, Vasan, Seshadri S., Cavaleri, Marco, Kaptein, Suzanne J.F., Baric, Ralph S., Delang, Leen, Tseng, Chien-Te, Lewis, Mark, Gralinski, Lisa E., Riveros-Balta, Ximena   +78 more
core   +1 more source

Association Between Individualized Education for Kidney Replacement Therapy Modality Selection and Peritoneal Dialysis Initiation: A Cross‐Sectional Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Peritoneal dialysis (PD) is an established home‐based kidney replacement therapy (KRT), but its uptake remains low in Japan. We evaluated whether individualized education in a dedicated outpatient clinic was associated with the initiation of PD.
Yasuko Ito, Ryuichi Yoshimura, Takaki Yamauchi, Yuta Funakoshi, Hirotaka Sonoda, Seiji Kobayashi, Hiroyuki Terawaki, Takafumi Ito   +7 more
wiley   +1 more source

Object-translocation induces event coding in the rat hippocampus

Communications Biology
Episodic memory is the ability to recall personally experienced events that are situated within specific spatial contexts. Within a navigation environment, salient objects can function as landmarks, and interactions with them can be encoded as distinct ...
Ya-Li Duan, Shu-Yi Hu, Xiao-Fan Ge, Jia-Li Long, Chu Deng, Yu-Ming Sun, Cheng-Ji Li, Rong Zhang, Xing Cai, Li Lu   +9 more
doaj   +1 more source